FB2025_01 , released February 20, 2025
Allele: Dmel\paraOcd-1
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General Information
Symbol
Dmel\paraOcd-1
Species
D. melanogaster
Name
FlyBase ID
FBal0221091
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sondergaard, 1973)
Progenitor genotype
Cytology
Description

Amino acid replacement: I1545M.

(Lindsay et al., 2008)

Amino acid replacement: G1571R.

(Lindsay et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,473,686..16,473,686 [-]
Nucleotide change:

G16473686C

Amino acid change:

G1571R | para-PA; G1524R | para-PAA; G1526R | para-PAB; G1524R | para-PAC; G1526R | para-PAD; G1548R | para-PAE; G1550R | para-PAF; G1529R | para-PAG; G1547R | para-PAH; G1526R | para-PAI; G1572R | para-PAJ; G1537R | para-PAK; G1551R | para-PAL; G1523R | para-PAM; G1583R | para-PAN; G1553R | para-PAO; G1537R | para-PAP; G1529R | para-PAQ; G1507R | para-PAS; G1496R | para-PAT; G1502R | para-PAW; G1539R | para-PAX; G1572R | para-PAY; G1551R | para-PAZ; G1571R | para-PB; G1572R | para-PBA; G1506R | para-PBB; G1496R | para-PBD; G1571R | para-PBF; G1571R | para-PBG; G1495R | para-PBH; G1571R | para-PC; G1554R | para-PD; G1548R | para-PE; G1548R | para-PF; G1527R | para-PG; G1537R | para-PH; G1519R | para-PI; G1540R | para-PJ; G1516R | para-PK; G1527R | para-PL; G1540R | para-PM; G1540R | para-PN; G1532R | para-PO; G1561R | para-PP; G1516R | para-PQ; G1519R | para-PR; G1540R | para-PS; G1550R | para-PT; G1558R | para-PU; G1537R | para-PV; G1542R | para-PW; G1565R | para-PX; G1578R | para-PY; G1529R | para-PZ

Reported amino acid change:

G1571R

Comment:

One of two amino acid substitutions in mutant. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lindsay et al., 2008)
point_mutation
X:16,473,762..16,473,762 [-]
Nucleotide change:

A16473762G

Amino acid change:

I1545M | para-PA; I1498M | para-PAA; I1500M | para-PAB; I1498M | para-PAC; I1500M | para-PAD; I1522M | para-PAE; I1524M | para-PAF; I1503M | para-PAG; I1521M | para-PAH; I1500M | para-PAI; I1546M | para-PAJ; I1511M | para-PAK; I1525M | para-PAL; I1497M | para-PAM; I1557M | para-PAN; I1527M | para-PAO; I1511M | para-PAP; I1503M | para-PAQ; I1481M | para-PAS; I1470M | para-PAT; I1476M | para-PAW; I1513M | para-PAX; I1546M | para-PAY; I1525M | para-PAZ; I1545M | para-PB; I1546M | para-PBA; I1480M | para-PBB; I1470M | para-PBD; I1545M | para-PBF; I1545M | para-PBG; I1469M | para-PBH; I1545M | para-PC; I1528M | para-PD; I1522M | para-PE; I1522M | para-PF; I1501M | para-PG; I1511M | para-PH; I1493M | para-PI; I1514M | para-PJ; I1490M | para-PK; I1501M | para-PL; I1514M | para-PM; I1514M | para-PN; I1506M | para-PO; I1535M | para-PP; I1490M | para-PQ; I1493M | para-PR; I1514M | para-PS; I1524M | para-PT; I1532M | para-PU; I1511M | para-PV; I1516M | para-PW; I1539M | para-PX; I1552M | para-PY; I1503M | para-PZ

Reported amino acid change:

I1545M

Comment:

One of two amino acid substitutions in mutant. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lindsay et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sodium conductance (INa) is significantly reduced in homozygous larvae compared to controls (measured from aCC or RP2 neurons) at 16, 22 and 28[o]C. The reduction is more marked at 16[o]C than 18[o]C.

      (Lindsay et al., 2008)

      At 25oC females behave normally, males walk in a reeling manner, fall over frequently and are unable to fly.

      (Sondergaard, 1973)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ocd1
      (Lindsay et al., 2008)
      Ocdts
      paraOcd-1
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0063107
      • FBal0013210
      References (3)