FB2025_01 , released February 20, 2025
Allele: Dmel\MycMB2A.UAS.Tag:HA
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General Information
Symbol
Dmel\MycMB2A.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0221193
Feature type
allele
Associated gene
Dmel\Myc
Associated Insertion(s)
Carried in Construct
M{UAS-Myc.HA.MB2A}
Key Links
Transgenic product class
missense_variant
(Schwinkendorf and Gallant, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schwinkendorf and Gallant, 2009)
Mutagen
in vitro construct
(Schwinkendorf and Gallant, 2009)
Progenitor genotype
MycWT.UAS.Tag:HA
(Schwinkendorf and Gallant, 2009)
Carried in construct
M{UAS-Myc.HA.MB2A}
Cytology
Description

dm amino acid residues "DCMW" in the MB2 domain have been replaced with "AAAA".

(Schwinkendorf and Gallant, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Myc
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing dmMB2A.Scer\UAS.T:HA1 under the control of Scer\GAL4GMR.PB show a significant increase in average ommatidial area compared to controls.

      Flies expressing dmMB2A.Scer\UAS.T:HA1 under the control of Scer\GAL4ap-md544 show a moderate bending down of the wings.

      Expression of dmMB2A.Scer\UAS.T:HA1 under the control of Scer\GAL4ap-md544 induces apoptosis in the larval wing disc.

      The average clonal area of clones in the larval wing disc expressing dmMB2A.Scer\UAS.T:HA1 under the control of Scer\GAL4Act5C.PP is increased compared to that of control clones.

      Expression of dmMB2A.Scer\UAS.T:HA1 under the control of Scer\GAL4αTub84B.PBb in eyes using the "ey-FLP" system results in an increase in ommatidial size compared to controls, both when the eyes are dm[+] and when they are mutant for dm4.

      (Schwinkendorf and Gallant, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      MycMB2A.Scer\UAS.T:HA1
      MycMB2A.Scer\UAS.T:Ivir\HA1
      MycMB2A.UAS.Tag:HA
      dmMB2A.Scer\UAS.T:HA1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)