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General Information
Symbol
Dmel\Gitex21C
Species
D. melanogaster
Name
FlyBase ID
FBal0221208
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion of 857bp which extends from the original insertion site into the Git open reading frame, deleting sequences encoding the N-terminal 109 amino acid residues.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Gitex21C mutant adults exhibit severely reduced brain size as compared to controls, and a subset exhibit defects in mushroom body structure, with terminated alpha or beta lobes, or divided alpha lobes.

100% of homozygous escapers have defective wing morphology; the wings are crumpled, uneven and sometimes curled upwards or not fully spread. Gitex21C/Gitex51C adults also have a defective wing phenotype.

Homozygous escapers produce fewer fertilised eggs than normal.

Embryos lacking both maternal and zygotic Git[+] function show guidance defects in the VO5 and VO6 muscles, which are characterised by bypass and mistargeting of the mutant muscles towards the ventral midline; VO5 and VO6 muscles from opposite sides of late stage mutant embryos inappropriately attach at the ventral midline or fuse together at their meeting point, instead of terminating at a distance from the midline as occurs in wild-type embryos. 60% of VO5/VO6 muscles are affected to various degrees. The VA3 muscle occasionally shows mistargeting towards the ventral midline. There is a low level of increase in the number of lateral transverse (18% of hemisegments and VA3 (7.5%) muscles in these embryos, and in addition, there are low frequencies of muscle shape or attachment defects in the VO1 and LO1 muscles.

Embryos lacking zygotic Git[+] function show a moderate increase in muscle numbers compared to controls for LT (7.5%) and VA3 (3.7%) muscles and they also show defects in VA3 shape and targeting.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Gitex21C mutants carrying ft8 clones generated using the eyFLP system show substantial overgrowth of the head, particularly in the ptilinum.

The increase in the number of interommatidial cells which is seen in homozygous hpoMGH1 clones generated using the eyFLP system is enhanced if the clones are also homozygous for Gitex21C.

The increase in the number of interommatidial cells which is seen in homozygous hpo5.1 clones generated using the eyFLP system is not further enhanced if the clones are also homozygous for Gitex21C.

Gitex21C Pak20 zygotic double mutant embryos show muscle targeting defects that are not seen in either zygotic mutant alone, and the double mutant embryos show a general disorganisation of their muscle pattern.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)