FB2025_05 , released December 11, 2025
Allele: Ecol\lexAVP16.Orco
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General Information
Symbol
Ecol\lexAVP16.Orco
Species
E. coli
Name
FlyBase ID
FBal0221467
Feature type
allele
Associated gene
Ecol\lexA
Associated Insertion(s)
Carried in Construct
P{Orco-LexA-VP16}
Also Known As
Orco-LexA, Orco-LexA::VP16, Or83b-LexA::VP16, Or83b-LexA
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lai and Lee, 2006)
Progenitor genotype
Carried in construct
P{Orco-LexA-VP16}
Cytology
Description

The Orco promoter controls expression of a lexA::VP16 driver.

(Lai and Lee, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
Orco
Encoded product / tool
lexA::VP16
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 17
      embryonic/larval olfactory receptor neuron

      Comment: 21h AEL

      (Prieto-Godino et al., 2012)
      larval stage
      embryonic/larval olfactory receptor neuron
      (Huang et al., 2016)
      adult stage
      antenna | restricted
      (Root et al., 2008)
      maxillary palp | restricted
      (Root et al., 2008)
      olfactory receptor neuron | subset
      (Root et al., 2008)
      adult olfactory receptor neuron
      (Gordon and Scott, 2009, Lai and Lee, 2006)
      adult antennal lobe | restricted
      (Root et al., 2008)
      adult olfactory receptor neuron | subset
      (Coates et al., 2017)
      adult antennal lobe glomerulus
      (Lai and Lee, 2006)
      Additional Information
      Statement
      Reference

      Drives expression in olfactory receptor neurons, which project to the antennal lobe.

      (FlyBase Curators, 2017)

      Ecol\lexAVP16.Orco drives expression in larval olfactory receptor neurons, which project to the antennal lobes of the larval brain.

      (Huang et al., 2016)

      EcollexAOrco.T:HsimVP16 is expressed in the adult olfactory receptor neurons. Using GFP reconstitution across synaptic partners (GRASP) contacts are found in the antennal lobe between olfactory receptor neurons and projection neurons labeled with ScerGAL4GH146 .

      (Gordon and Scott, 2009)
       
      Marker for
      adult olfactory receptor neuron
      (Gordon and Scott, 2009)
      Reflects expression of
      Orco
      (Huang et al., 2016, Prieto-Godino et al., 2012, Gordon and Scott, 2009, Root et al., 2008, Lai and Lee, 2006)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Ecol\lexAOr83b.T:Hsim\VP16 can drive expression of constructs containing Ecol\lexAop operator sequences. The protein produced is not affected by the presence Scer\GAL80 protein.

      (Lai and Lee, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ecol\lexAOr83b.T:Hsim\VP16
      Ecol\lexAOrco.T:Hsim\VP16
      Ecol\lexAVP16.Orco
      Name Synonyms
      Secondary FlyBase IDs
        References (25)