FlyBase Allele Report: Dmel\TBPH[Δ23]

General Information

Symbol

Dmel\TBPH^Δ23

Species

D. melanogaster

Name

FlyBase ID

FBal0221488

Feature type

allele

Associated gene

Dmel\TBPH

Associated Insertion(s)

Carried in Construct

Also Known As

tbphΔ23

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Feiguin et al., 2009)

Mutagen

Delta2-3 transposase

(Feiguin et al., 2009)

Progenitor genotype

P{EPgy2}TBPH^EY10530

(Feiguin et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of 1616bp of genomic DNA with complete elimination of the inserted element. The breakpoints of the deletion are 2R:19748477-19750093 .

(Feiguin et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:23,860,954..23,862,570 [-]

Comment:

A 1616bp deletion resulting from the excision of P{EPgy2}TBPHEY10530. The P element was completely excised.

(Feiguin et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis type 10

CEA with TBPH^Δ142

(Vanden Broeck et al., 2015)

CEC

(Ervilha Pereira et al., 2023)

CEA

(Romano et al., 2021, Donde et al., 2020, Donde et al., 2019, Langellotti et al., 2018)

CEA with TBPH^GD6943

(Romano et al., 2021, Langellotti et al., 2018)

CEA with Hsap\TARDBP^{12xQN.UAS.EGFP}

(Cragnaz et al., 2015)

model of amyotrophic lateral sclerosis

CEA with TBPH¹

(Baldwin et al., 2016)

CEA

(Langellotti et al., 2016, Romano et al., 2014)

model of neurodegenerative disease

CEA

(Feiguin et al., 2009)

CEA with TBPH^GD6943

(Romano et al., 2014)

CEA with TBPH^RNAi.UAS.cUa

(Appocher et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis type 10

is ameliorated by Hsap\TARDBP^{W385IfsTer10.UAS}

(Ervilha Pereira et al., 2023)

is ameliorated by Atg7^UAS.cUa

(Donde et al., 2020)

is ameliorated by Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

model of neurodegenerative disease

is ameliorated by Hsap\TARDBP^UAS.Tag:FLAG

(Feiguin et al., 2009)

model of amyotrophic lateral sclerosis

is ameliorated by Syx1A^UAS.cBa

(Romano et al., 2014)

ameliorates Perry syndrome

modeled by DCTN1-p150^{G50R.UAS.Tag:HA}

(Hosaka et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior

(Romano et al., 2015)

abnormal locomotor behavior, with Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, TBPH^GD6943

(Romano et al., 2015)

abnormal locomotor behavior, with Scer\GAL4^elav.PLu, TBPH^GD6943

(Feiguin et al., 2009)

abnormal locomotor behavior (with Df(2R)BSC660)

(Wang et al., 2011)

abnormal locomotor behavior | adult stage

(Donde et al., 2019)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU, TBPH^GD6943

(Romano et al., 2014)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU, TBPH^RNAi.UAS.cUa

(Appocher et al., 2017)

abnormal locomotor behavior | adult stage (with TBPH¹)

(Baldwin et al., 2016)

abnormal locomotor behavior | adult stage | dominant

(Hosaka et al., 2017)

abnormal locomotor behavior | adult stage | dominant | progressive

(Hosaka et al., 2017)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Tub.PU, TBPH^GD6943

(Romano et al., 2014)

abnormal locomotor behavior | adult stage | recessive

(Feiguin et al., 2009)

abnormal locomotor behavior | third instar larval stage

(Langellotti et al., 2016, Romano et al., 2014)

abnormal locomotor behavior | third instar larval stage (with Df(2R)BSC610)

(Deshpande et al., 2016)

abnormal locomotor behavior | third instar larval stage (with TBPH¹)

(Baldwin et al., 2016)

abnormal neuroanatomy

(Romano et al., 2015)

abnormal neuroanatomy, with Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, TBPH^GD6943

(Romano et al., 2015)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PU, TBPH^GD6943

(Romano et al., 2014)

abnormal neuroanatomy | third instar larval stage

(Donde et al., 2019, Deshpande et al., 2016, Feiguin et al., 2009)

abnormal neuroanatomy | third instar larval stage (with Df(2R)BSC610)

(Deshpande et al., 2016)

abnormal neurophysiology, with Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, TBPH^GD6943

(Romano et al., 2015)

decreased cell number (with TBPH^Δ142)

(Vanden Broeck et al., 2015)

decreased cell number | adult stage | dominant

(Hosaka et al., 2017)

lethal - all die before end of P-stage (with TBPH^Δ142)

(Vanden Broeck et al., 2015)

lethal - all die before end of P-stage | recessive

(Feiguin et al., 2009)

lethal - all die before end of pupal stage (with TBPH^Δ142)

(Vanden Broeck et al., 2013)

partially lethal

(Ervilha Pereira et al., 2023)

partially lethal - majority die

(Donde et al., 2019)

partially lethal - majority die (with Df(2R)BSC660)

(Wang et al., 2011)

partially lethal - majority die (with TBPH¹)

(Baldwin et al., 2016)

partially lethal - majority die (with TBPH^Δ142)

(Mallik et al., 2018)

short lived

(Donde et al., 2019, Feiguin et al., 2009)

short lived, with Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, TBPH^GD6943

(Romano et al., 2015)

short lived, with Scer\GAL4^elav.PU, TBPH^GD6943

(Romano et al., 2014)

short lived, with Scer\GAL4^Tub.PU, TBPH^GD6943

(Romano et al., 2014)

short lived (with Df(2R)BSC660)

(Wang et al., 2011)

short lived (with TBPH¹)

(Baldwin et al., 2016)

short lived | dominant

(Hosaka et al., 2017)

some die during pharate adult stage | recessive

(Feiguin et al., 2009)

uncoordinated | adult stage (with TBPH¹)

(Baldwin et al., 2016)

Phenotype Manifest In

adult CCAP neuron (with TBPH^Δ142)

(Vanden Broeck et al., 2015)

dopaminergic PPL1 neuron | adult stage

(Hosaka et al., 2017)

embryonic/larval motor neuron | third instar larval stage (with TBPH¹)

(Baldwin et al., 2016)

embryonic/larval neuromuscular junction

(Feiguin et al., 2009)

embryonic/larval neuromuscular junction, with Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, TBPH^GD6943

(Romano et al., 2015)

embryonic/larval neuromuscular junction | second instar larval stage

(Godena et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage

(Donde et al., 2019, Deshpande et al., 2016, Godena et al., 2011)

microtubule | third instar larval stage

(Godena et al., 2011)

neuronal dense core vesicle | third instar larval stage

(Hosaka et al., 2017)

neuropil | adult stage, with Scer\GAL4^elav.PU, TBPH^GD6943

(Romano et al., 2014)

NMJ bouton | second instar larval stage

(Godena et al., 2011)

NMJ bouton | third instar larval stage

(Donde et al., 2019, Deshpande et al., 2016, Godena et al., 2011)

NMJ bouton | third instar larval stage (with Df(2R)BSC610)

(Deshpande et al., 2016)

PNS glial cell

(Romano et al., 2015)

presynaptic active zone | third instar larval stage

(Hosaka et al., 2017)

synapse (with TBPH^Δ142)

(Miskiewicz et al., 2014)

synaptic vesicle (with TBPH^Δ142)

(Miskiewicz et al., 2014)

synaptic vesicle | third instar larval stage

(Hosaka et al., 2017)

t-bar (with TBPH^Δ142)

(Miskiewicz et al., 2014)

terminal bouton | third instar larval stage

(Hosaka et al., 2017)

type I bouton | third instar larval stage

(Feiguin et al., 2009)

Detailed Description

Statement

Reference

The few TBPH^Δ23 homozygous adult escapers are short lived and show severely impaired locomotion compared to controls. Their third instar larval neuromuscular junction exhibits fewer branches and boutons than controls.

(Donde et al., 2019)

TBPH^Δ23/+ adult flies also expressing TBPH^{dsRNA.Scer\UAS.cUa} (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^elav.PU display significant locomotor deficit in climbing assays.

(Appocher et al., 2017)

TBPH^Δ23 heterozygous adults exhibit a significant decrease in lifespan and a significant and progressive decrease in climbing performance (detected at day 45, but not day 5, post eclosion); 45 days old adults also exhibit a significant increase in spontaneous locomotor activity and a significant decrease in the number of PPL1 neurons, but not of PPM1/2 and PPM3 neurons, as compared to controls.

The third instar larval neuromuscular junctions of TBPH^Δ23 heterozygotes exhibit significant increases in the density of dense core vesicles at synaptic terminal boutons, but do not present significant changes in the size of dense core vesicles at synaptic terminal boutons, in the size or number of terminal boutons, in the density of active zones at the terminal boutons, or in the number of synaptic vesicles at active zones, as compared to controls; the respective axonal dense core vesicles exhibit defective transport, as shown by the significant decrease in retrograde transport, but do not exhibit significant changes in size, as compared to controls. Neurotransmission across these neuromuscular junctions does exhibit significant defects in miniature excitatory junction potential frequency and amplitude, paired-pulse ratio, excitatory junction potential amplitude or quantal content, as compared to controls.

(Hosaka et al., 2017)

TBPH¹/TBPH^Δ23 transheterozygotes are semi-lethal and the eclosing adults are uncoordinated, are not able to climb and die within 5 days. These mutants also show impaired larval locomotion in crawling assays, as compared to controls.

TBPH¹/TBPH^Δ23 transheterozygotes show a decrease in axonal transport of mitochondria (i.e. a significant decrease in anterograde transport and a significant increase in the stationary fraction), but not of (NPY-positive) vesicles, in third instar larval motor neurons, as compared to controls.

(Baldwin et al., 2016)

The fraction of small neuromuscular junction (NMJ) boutons is significantly increased in TBPH^Δ23 homozygotes and TBPH^Δ23/Df(2R)BSC610 third instar larvae and in the TBPH^Δ23 homozygotes the overall NMJ area is also reduced. Number of NMJ boutons as well as the length of the longest NMJ branch is comparable to wild-type. It does not disrupt the axonal transport of tkv-mCherry particles (expressed using the tkv^{Scer\UAS.RD.T:Disc\RFP-mCherry} driven by Scer\GAL4^VGlut.PD) but decreases particle stall duration compared to controls.

TBPH^Δ23/Df(2R)BSC610 third instar larvae display strongly reduced rates of larval crawling.

(Deshpande et al., 2016)

TBPH^Δ23 mutant third instar larvae display reduced motility (measured as number of peristaltic waves per unit of time) compared to controls.

(Langellotti et al., 2016)

Expression of TBPH^GD6943 under the control of Scer\GAL4^repo.PU (in combination with Dcr-2 expression for efficient RNAi) in a TBPH^Δ23 heterozygous background results in strong motility defects, as well as consistent reduction of life span, compared with wild-type

(Romano et al., 2015)

TBPH^Δ142/TBPH^Δ23 flies have significantly fewer CCAP/bursicon neurons (counted in the ventral nerve cord) than controls.

(Vanden Broeck et al., 2015)

TBPH^Δ23/TBPH^Δ142 exhibit a decrease in the top size of synaptic T-bars and a fall in the number of tethered vesicles. The EJC amplitude and quantal content is not affected in these mutants.

(Miskiewicz et al., 2014)

TBPH^Δ23/+ mutants do not exhibit significant climbing defects nor any significant reduction in life span, as compared to controls.

Flies expressing TBPH^GD6943 under the control of Scer\GAL4^elav.PU in a TBPH^Δ23/+ mutant background exhibit significant climbing defects, a severe reduction in life span, and degeneration of the neuropil, as compared to controls.

(Romano et al., 2014)

Flies expressing TBPH^GD6943 in a TBPH^Δ23/+ mutant background under the control of Scer\GAL4^tub.PU, and restricted to the adult stage using Scer\GAL80^ts.αTub84B, exhibit progressive climbing defects and reduced lifespan.

Larvae expressing TBPH^GD6943 under the control of Scer\GAL4^tub.PU from the third instar larval stage onward (using Scer\GAL80^ts.αTub84B) in a TBPH^Δ23/+ background) exhibit locomotor defects from 24 hours after the temperature shift. These alterations in fly motility are not associated with anatomical modifications in the number of synaptic boutons or motoneuron terminal branches at the NMJ, except for the presence of subtle alterations in the morphology of the synaptic boutons compared to controls.

(Romano et al., 2014)

The NMJ morphology of TBPH^Δ23 mutant first instar larvae is similar to wild type. Presynaptic ramifications and muscular insertions in the mutant motor axons appear normal in. In contrast, significant abnormalities are observed in second instar larval NMJs, and these are even more evident at the third instar larval stage. Muscle development appears normal in TBPH^Δ23 mutant flies; no differences in organ growth, cytoskeletal organisation or postsynaptic differentiation are observed.

TBPH^Δ23 mutant synaptic boutons on muscles 6 and 7 in third instar larvae appear deformed and are irregularly spaced along the terminal axons with several fused or elongated silhouettes and clear loss of their characteristic round-smooth shape. There are fewer boutons and terminal branches per segment than in controls. Microtubule stability is significantly reduced in the distal boutons compared to controls.

(Godena et al., 2011)

Compared with controls, only about 20% of the expected TBPH^Δ23/Df(2R)BSC660 mutants survive to adulthood. The escapers do not show any defects in eye, wing or genital development.

Compared with controls, TBPH^Δ23/Df(2R)BSC660 mutants show a dramatic reduction of locomotor speed.

Compared with wild-type, the survival of TBPH^Δ23/Df(2R)BSC660 mutants is markedly reduced.

Larval neuromuscular junction synapse morphology appears normal in TBPH^Δ23/Df(2R)BSC660 mutants.

(Wang et al., 2011)

Homozygotes survive embryogenesis and more than 60% reach the pupal stage. However, only 21% of homozygotes eclose, with 32% becoming trapped in the pupal case. Homozygous adults that eclose are morphologically normal, but they have dramatic locomotive defects, in both walking and climbing assays.

Homozygous adults have a reduced lifespan compared to controls.

Flies expressing TBPH^GD6943 under the control of Scer\GAL4^elav.PLu in a TBPH^Δ23/+ background show defects in both walking and climbing assays.

The number of type 1b and 1s boutons and the number of synaptic branches at the neuromuscular junction of muscles 6 and 7 is reduced in homozygous larvae compared to controls.

(Feiguin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by CG42458^GD16040, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by CG42458^KK113285, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by sqd^GD8593/Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/rump^GD14202

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/rump^KK102889

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by CG30122^KK100713, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Hrb87F^KK108162, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/glo^GD12082

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by glo^KK108457/Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/heph^GD10126

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/heph^KK108057

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by HnRNP-K^GD1382, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by HnRNP-K^KK106619, Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav.PU/sm^GD12545

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^RNAi.UAS.cUa has abnormal locomotor behavior | adult stage phenotype, enhanceable by sm^KK108588/Scer\GAL4^elav.PU

(Appocher et al., 2017)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943 has short lived phenotype, enhanceable by Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has short lived phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal neuroanatomy | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943 has abnormal locomotor behavior | adult stage phenotype, enhanceable by Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

Suppressed by

Statement

Reference

TBPH^Δ23 has increased mortality during development phenotype, suppressible by Hsap\TARDBP^UAS.cEPa/Scer\GAL4^Toll-6-D42

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^{A382T.UAS.cEPa}

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible by Hsap\TARDBP^{W385IfsTer10.UAS}/Scer\GAL4^Toll-6-D42

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^{M337V.UAS.cEPa}

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible by Hsap\TARDBP^{W385IfsTer10.UAS}/Scer\GAL4^nSyb.PS

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible | partially by Hsap\TARDBP^UAS.cEPa/Scer\GAL4^nSyb.PS

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^nSyb.PS/Hsap\TARDBP^{A382T.UAS.cEPa}

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^nSyb.PS/Hsap\TARDBP^{M337V.UAS.cEPa}

(Ervilha Pereira et al., 2023)

TBPH^Δ23 has short lived phenotype, suppressible | partially by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has short lived phenotype, suppressible | partially by Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible by Scer\GAL4^ple.PF/DCTN1-p150^UAS.Tag:HA

(Hosaka et al., 2017)

TBPH^Δ23 has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH^Δ23 has short lived | dominant phenotype, suppressible by Scer\GAL4^ple.PF/DCTN1-p150^UAS.Tag:HA

(Hosaka et al., 2017)

TBPH^Δ23 has short lived | dominant phenotype, suppressible | partially by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH¹/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by caz^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by caz^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by Scer\GAL4^Toll-6-D42/caz^{P398L.10x.UAS.Tag:FLAG}

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Scer\GAL4^Toll-6-D42/caz^{P398L.10x.UAS.Tag:FLAG}

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by Hsap\TARDBP^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\TARDBP^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Hsap\TARDBP^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

Df(2R)BSC610/TBPH^Δ23 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible | partially by Rab11^N124I.UAS/Scer\GAL4^VGlut1.PD

(Deshpande et al., 2016)

TBPH^Δ23 has abnormal locomotor behavior phenotype, suppressible by Scer\GAL4^repo.PU/Eaat1^UAS.Exel

(Romano et al., 2015)

TBPH^Δ23 has abnormal locomotor behavior phenotype, suppressible | partially by Scer\GAL4^repo.PU/Hsap\TARDBP^UAS.Tag:FLAG

(Romano et al., 2015)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of P-stage phenotype, suppressible | partially by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{G287S.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\TARDBP^{A315T.UAS.cVBa}/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of P-stage phenotype, suppressible | partially by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{D169G.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of P-stage phenotype, suppressible | partially by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{A90V.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\TARDBP^UAS.cVBa/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has decreased cell number phenotype, suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{D169G.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has decreased cell number phenotype, suppressible by Hsap\TARDBP^UAS.cVBa/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ23 has abnormal locomotor behavior phenotype, suppressible by Scer\GAL4^elav.PU/Syx1A^UAS.cBa

(Romano et al., 2014)

TBPH^Δ23 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Syx1A^UAS.cBa

(Romano et al., 2014)

Scer\GAL4^Tub.PU, TBPH^Δ23, TBPH^GD6943 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Scer\GAL4^Tub.PU/Syx1A^UAS.cBa

(Romano et al., 2014)

TBPH^Δ142/TBPH^Δ23 has lethal - all die before end of pupal stage phenotype, suppressible by Scer\GAL4^nSyb.PU/Map205^GD8458

(Vanden Broeck et al., 2013)

Df(2R)BSC660/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by Scer\GAL4^elav-C155/caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Df(2R)BSC660/TBPH^Δ23 has short lived phenotype, suppressible by Scer\GAL4^elav-C155/caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Df(2R)BSC660/TBPH^Δ23 has abnormal locomotor behavior phenotype, suppressible | partially by Scer\GAL4^elav-C155/caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Df(2R)BSC660/TBPH^Δ23 has partially lethal - majority die phenotype, suppressible by Scer\GAL4^elav-C155/Hsap\TARDBP^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Df(2R)BSC660/TBPH^Δ23 has abnormal locomotor behavior phenotype, suppressible by Scer\GAL4^elav-C155/Hsap\TARDBP^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Df(2R)BSC660/TBPH^Δ23 has short lived phenotype, suppressible by Scer\GAL4^elav-C155/Hsap\TARDBP^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

TBPH^Δ23 has short lived phenotype, suppressible | partially by Hsap\TARDBP^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Feiguin et al., 2009)

TBPH^Δ23 has abnormal locomotor behavior | recessive | adult stage phenotype, suppressible by Hsap\TARDBP^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Feiguin et al., 2009)

TBPH^Δ23 has abnormal locomotor behavior | recessive | adult stage phenotype, suppressible by Hsap\TARDBP^UAS.Tag:FLAG/Scer\GAL4^elav.PLu

(Feiguin et al., 2009)

NOT suppressed by

Statement

Reference

TBPH^Δ23 has short lived phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^N.UAS.GFP

(Donde et al., 2019)

TBPH^Δ23 has short lived phenotype, non-suppressible by Scer\GAL4^hs.PU/Hsap\TARDBP^N.UAS.GFP

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/Hsap\TARDBP^N.UAS.GFP

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^hs.PU/Hsap\TARDBP^N.UAS.GFP

(Donde et al., 2019)

TBPH^Δ23 has short lived phenotype, non-suppressible by Scer\GAL4^hs.PU, Hsap\TARDBP^{CTR.F147L.F149L.UAS}/Hsap\TARDBP^{CTR.F147L.F149L.UAS}

(Donde et al., 2019)

TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^hs.PU, Hsap\TARDBP^{CTR.F147L.F149L.UAS}/Hsap\TARDBP^{CTR.F147L.F149L.UAS}

(Donde et al., 2019)

TBPH^Δ142/TBPH^Δ23 has partially lethal - majority die phenotype, non-suppressible by Df(3R)Xrp1-Plus/+

(Mallik et al., 2018)

TBPH^Δ23 has abnormal locomotor behavior | dominant | adult stage phenotype, non-suppressible by Scer\GAL4^ple.PF/DCTN1-p150^UAS.Tag:HA

(Hosaka et al., 2017)

TBPH^Δ23 has abnormal locomotor behavior | dominant | adult stage phenotype, non-suppressible by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by caz^{UAS.x10.Tag:FLAG}/Scer\GAL4^Toll-6-D42

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Scer\GAL4^Toll-6-D42/caz^{P398L.10x.UAS.Tag:FLAG}

(Baldwin et al., 2016)

TBPH^Δ142/TBPH^Δ23 has decreased cell number phenotype, non-suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{G287S.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has decreased cell number phenotype, non-suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{A90V.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has decreased cell number phenotype, non-suppressible by Hsap\TARDBP^{A315T.UAS.cVBa}/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ23 has lethal - all die before end of pupal stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Syx1A^UAS.cBa

(Romano et al., 2014)

TBPH^Δ23 has abnormal locomotor behavior | larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\MAPT^UAS.cWa

(Godena et al., 2011)

Enhancer of

Statement

Reference

TBPH^RNAi.UAS.cUa, TBPH[+], TBPH^Δ23, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of HnRNP-K^GD1382, Scer\GAL4^elav.PU

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, TBPH[+], TBPH^Δ23, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of HnRNP-K^KK106619, Scer\GAL4^elav.PU

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, heph^GD10126

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, heph^KK108057

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, sm^GD12545

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, sm^KK108588

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, TBPH[+], TBPH^Δ23, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hrb87F^KK108162, Scer\GAL4^elav.PU

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, glo^GD12082

(Appocher et al., 2017)

TBPH^RNAi.UAS.cUa, Scer\GAL4^elav.PU, TBPH[+], TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PU, glo^KK108457

(Appocher et al., 2017)

TBPH[+]/TBPH^Δ23 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

TBPH[+]/TBPH^Δ23 is an enhancer of short lived phenotype of Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

NOT Enhancer of

Statement

Reference

Df(2R)BSC660/TBPH^Δ23, Scer\GAL4^RapGAP1-OK6 is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^RapGAP1-OK6, caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Suppressor of

Statement

Reference

TBPH[+]/TBPH^Δ23 is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor of short lived phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor of abnormal size | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of short lived phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of abnormal size | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor of abnormal size | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of abnormal neurophysiology | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

NOT Suppressor of

Statement

Reference

TBPH[+]/TBPH^Δ23 is a non-suppressor of abnormal size | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

Df(2R)BSC660/TBPH^Δ23, Scer\GAL4^RapGAP1-OK6 is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^RapGAP1-OK6, caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Other

Statement

Reference

Hrb27C^GD6964, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23, TBPH^RNAi.UAS.cUa has lethal phenotype

(Appocher et al., 2017)

Scer\GAL4^elav.PU, Syp^GD9477, TBPH[+]/TBPH^Δ23, TBPH^RNAi.UAS.cUa has paralytic | adult stage phenotype

(Appocher et al., 2017)

Scer\GAL4^elav.PU, Syp^KK108062, TBPH[+]/TBPH^Δ23, TBPH^RNAi.UAS.cUa has paralytic | adult stage phenotype

(Appocher et al., 2017)

Hrb27C^KK109074, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23, TBPH^RNAi.UAS.cUa has lethal phenotype

(Appocher et al., 2017)

Hsap\TARDBP^{A315T.UAS.cVBa}, Scer\GAL4^nSyb.PU, TBPH^Δ142/TBPH^Δ23 has short lived phenotype

(Vanden Broeck et al., 2015)

Hsap\TARDBP^{A90V.UAS.cVBa}, Scer\GAL4^nSyb.PU, TBPH^Δ142/TBPH^Δ23 has short lived phenotype

(Vanden Broeck et al., 2015)

Hsap\TARDBP^{D169G.UAS.cVBa}, Scer\GAL4^nSyb.PU, TBPH^Δ142/TBPH^Δ23 has short lived phenotype

(Vanden Broeck et al., 2015)

Hsap\TARDBP^{G287S.UAS.cVBa}, Scer\GAL4^nSyb.PU, TBPH^Δ142/TBPH^Δ23 has short lived phenotype

(Vanden Broeck et al., 2015)

Hsap\TARDBP^UAS.cVBa, Scer\GAL4^nSyb.PU, TBPH^Δ142/TBPH^Δ23 has short lived phenotype

(Vanden Broeck et al., 2015)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has abnormal neuroanatomy | adult stage phenotype

(Romano et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

TBPH^Δ23 has terminal bouton | third instar larval stage phenotype, enhanceable by DCTN1-p150^UAS.Tag:HA/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH^Δ23 has neuronal dense core vesicle | third instar larval stage phenotype, enhanceable by DCTN1-p150^UAS.Tag:HA/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH^Δ23 has terminal bouton | third instar larval stage phenotype, enhanceable by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH^Δ23 has neuronal dense core vesicle | third instar larval stage phenotype, enhanceable by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has neuropil | adult stage phenotype, enhanceable by TBPH^GD6943, Scer\GAL4^elav.PU

(Romano et al., 2014)

Scer\GAL4^elav.PU, TBPH^Δ23, TBPH^GD6943 has neuropil | adult stage phenotype, enhanceable by Hrb98DE^JF01249, Scer\GAL4^elav.PU

(Romano et al., 2014)

Suppressed by

Statement

Reference

TBPH^Δ23 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has NMJ bouton | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^hs.PU/Hsap\TARDBP^CTR.UAS

(Donde et al., 2019)

TBPH^Δ23 has dopaminergic PPL1 neuron | adult stage phenotype, suppressible | partially by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^ple.PF

(Hosaka et al., 2017)

TBPH^Δ23 has neuronal dense core vesicle | third instar larval stage phenotype, suppressible by DCTN1-p150^UAS.Tag:HA/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH^Δ23 has neuronal dense core vesicle | third instar larval stage phenotype, suppressible by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH^Δ23 has synaptic vesicle | third instar larval stage phenotype, suppressible by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

TBPH¹/TBPH^Δ23 has embryonic/larval motor neuron | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^CCAP.PU/caz^{P398L.10x.UAS.Tag:FLAG}

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has embryonic/larval motor neuron | third instar larval stage phenotype, suppressible by Scer\GAL4^CCAP.PU/Hsap\TARDBP^{UAS.x10.Tag:FLAG}

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 has embryonic/larval motor neuron | third instar larval stage phenotype, suppressible by Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}/Scer\GAL4^CCAP.PU

(Baldwin et al., 2016)

TBPH^Δ142/TBPH^Δ23 has adult CCAP neuron phenotype, suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{D169G.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has adult CCAP neuron phenotype, suppressible by Hsap\TARDBP^UAS.cVBa/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ23 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Syx1A^UAS.cBa

(Romano et al., 2014)

TBPH^Δ23 has type I bouton | third instar larval stage phenotype, suppressible by Hsap\TARDBP^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Feiguin et al., 2009)

TBPH^Δ23 has embryonic/larval neuromuscular junction phenotype, suppressible by Hsap\TARDBP^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Feiguin et al., 2009)

NOT suppressed by

Statement

Reference

TBPH^Δ23 has neuronal dense core vesicle | third instar larval stage phenotype, non-suppressible by DCTN1-p150^{G50R.UAS.Tag:HA}/Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH¹/TBPH^Δ23 has embryonic/larval motor neuron | third instar larval stage phenotype, non-suppressible by Scer\GAL4^CCAP.PU/caz^{UAS.x10.Tag:FLAG}

(Baldwin et al., 2016)

TBPH^Δ142/TBPH^Δ23 has adult CCAP neuron phenotype, non-suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{G287S.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has adult CCAP neuron phenotype, non-suppressible by Scer\GAL4^nSyb.PU/Hsap\TARDBP^{A90V.UAS.cVBa}

(Vanden Broeck et al., 2015)

TBPH^Δ142/TBPH^Δ23 has adult CCAP neuron phenotype, non-suppressible by Hsap\TARDBP^{A315T.UAS.cVBa}/Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2015)

TBPH^Δ23 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by futsch^N94/Scer\GAL4^elav.PU/futsch[+]/TBPH^UAS.Tag:FLAG

(Godena et al., 2011)

TBPH^Δ23 has NMJ bouton | third instar larval stage phenotype, non-suppressible by futsch^N94/Scer\GAL4^elav.PU/futsch[+]/TBPH^UAS.Tag:FLAG

(Godena et al., 2011)

TBPH^Δ23 has microtubule | third instar larval stage phenotype, non-suppressible by futsch^N94/Scer\GAL4^elav.PU/futsch[+]/TBPH^UAS.Tag:FLAG

(Godena et al., 2011)

TBPH^Δ23 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\MAPT^UAS.cWa

(Godena et al., 2011)

TBPH^Δ23 has NMJ bouton | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\MAPT^UAS.cWa

(Godena et al., 2011)

TBPH^Δ23 has microtubule | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\MAPT^UAS.cWa

(Godena et al., 2011)

Enhancer of

Statement

Reference

TBPH[+]/TBPH^Δ23 is an enhancer of neuronal dense core vesicle | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is an enhancer of terminal bouton | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

NOT Enhancer of

Statement

Reference

TBPH[+]/TBPH^Δ23 is a non-enhancer of neuronal dense core vesicle | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a non-enhancer of terminal bouton | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

Df(2R)BSC660/TBPH^Δ23, Scer\GAL4^RapGAP1-OK6 is a non-enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^RapGAP1-OK6, caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Suppressor of

Statement

Reference

TBPH[+]/TBPH^Δ23 is a suppressor of neuronal dense core vesicle | third instar larval stage phenotype of DCTN1-p150^UAS.Tag:HA, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of terminal bouton phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor of presynaptic active zone | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of neuronal dense core vesicle | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a suppressor | partially of terminal bouton | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

NOT Suppressor of

Statement

Reference

TBPH[+]/TBPH^Δ23 is a non-suppressor of presynaptic active zone | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a non-suppressor | partially of neuronal dense core vesicle | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Hosaka et al., 2017)

TBPH[+]/TBPH^Δ23 is a non-suppressor of synaptic vesicle | third instar larval stage phenotype of DCTN1-p150^{G50R.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6

(Hosaka et al., 2017)

Df(2R)BSC660/TBPH^Δ23, Scer\GAL4^RapGAP1-OK6 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^RapGAP1-OK6, caz^{UAS.x10.Tag:FLAG}

(Wang et al., 2011)

Other

Statement

Reference

Hrb98DE^JF01249, Scer\GAL4^elav.PU, TBPH[+]/TBPH^Δ23 has neuropil | adult stage phenotype

(Romano et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced climbing ability of adult flies heterozygous for TBPH^Δ23 and also expressing TBPH^{dsRNA.Scer\UAS.cUa} (together with UAS-Dicer2 to enhance RNAi efficiency) driven by Scer\GAL4^elav.PU is strongly enhanced by co-expression of any of the following: CG42458^GD16040, CG42458^KK113285, sqd^GD8593, rump^GD14202, rump^KK102889, CG30122^KK100713 (which on their own do not affect adult locomotion), as well as by co-expression of: Hrb87F^KK108162, glo^GD12082, glo^KK108457, heph^GD10126, heph^KK108057, HnRNP-K^GD1382, HnRNP-K^KK106619, sm^GD12545 and sm^KK108588 (which own their own also induce climbing ability defects that are synergistically enhanced by combination with the TBPH hypomorphic test line).

Animals expressing either Hrb27C^GD6964 or Hrb27C^KK109074 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^elav.PU in either wild-type or TBPH^Δ23/+; TBPH^{dsRNA.Scer\UAS.cUa} background are lethal.

Adult flies expressing either Syp^GD9477 or Syp^KK108062 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^elav.PU in either wild-type or TBPH^Δ23/+; TBPH^{dsRNA.Scer\UAS.cUa} background appear to be completely paralyzed.

(Appocher et al., 2017)

The decreases in adult climbing performance and in lifespan exhibited by TBPH^Δ23 heterozygotes or exhibited upon the expression of either DCTN1-p150^{Scer\UAS.T:Ivir\HA1} or DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ple.PF or exhibited by TBPH^Δ23 heterozygotes are fully or partially suppressed in individuals that simultaneously express either DCTN1-p150^{Scer\UAS.T:Ivir\HA1} or DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ple.PF and are heterozygous for TBPH^Δ23. The decreased number of PPL1 neurons in the adult brain, but not the spontaneous locomotion defects, presented by 45 days old TBPH^Δ23 heterozygotes are also partially suppressed by the expression of either DCTN1-p150^{Scer\UAS.T:Ivir\HA1} or DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ple.PF.

Individuals expressing DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Toll-6-D42 in a TBPH^Δ23 heterozygous background exhibit defects in the axonal transport of dense core vesicles at the third instar larval neuromuscular junction which are intermediate between the defects observed upon the expression of DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Toll-6-D42 and the defects observed in TBPH^Δ23 heterozygotes. These individuals also exhibit the same increase in the number synaptic vesicles at active zones in the third instar larval neuromuscular junction as upon the expression of DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Toll-6-D42 alone, rather than the decrease in the number synaptic vesicles observed in TBPH^Δ23 heterozygotes.

The increased density of dense core vesicles at distal terminal boutons in the third instar larval junction of TBPH^Δ23 heterozygotes are enhanced by the Scer\GAL4^Toll-6-D42-driven expression of DCTN1-p150^{Scer\UAS.T:Ivir\HA1}, but not of DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1}, wheres their increased density at proximal terminal boutons is partially and fully suppressed by the expression of DCTN1-p150^{Scer\UAS.T:Ivir\HA1} and DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1}, respectively, under the control of Scer\GAL4^Toll-6-D42.

Heterozygosity for TBPH^Δ23 suppresses the increased size of axonal dense core vesicles, and enhances the increased density of dense core vesicles in distal terminal boutons at the third instar larval neuromuscular junction of individuals expressing DCTN1-p150^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Toll-6-D42.

Heterozygosity for TBPH^Δ23 fully or partially suppresses the following third instar larval neuromuscular junction defects induced by the expression of DCTN1-p150^{G50R.Scer\UAS.T:Ivir\HA1} : increased size of proximal terminal boutons, increased density of active zones at terminal boutons, decreased excitatory junction potential amplitude and decreased quantal content (Scer\GAL4^RapGAP1-OK6-driven expression); increased density of dense core vesicles in distal terminal boutons, but not in axons, and defective axonal transport of dense core vesicles (Scer\GAL4^Toll-6-D42-driven expression). Heterozygosity for TBPH^Δ23 does not significantly suppress or enhance the following neuromuscular junction defects: increased size of distal terminal boutons, decreased number of synaptic vesicles at the active zone (Scer\GAL4^RapGAP1-OK6-driven expression); and increased size of dense core vesicles in axons (Scer\GAL4^Toll-6-D42-driven expression).

(Hosaka et al., 2017)

The semi-lethality and the decreased adult climbing capacity, but not the decreased third instar larval crawling capacity,observed in TBPH¹/TBPH^Δ23 transheterozygotes are suppressed by the expression of either caz^{Scer\UAS.x10.T:Zzzz\FLAG} or caz^{P398L.10x.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^Toll-6-D42. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also partially suppressed by the expression of caz^{P398L.10x.Scer\UAS.T:Zzzz\FLAG}, but not caz^{Scer\UAS.x10.T:Zzzz\FLAG}, under the control of Scer\GAL4^CCAP.PI.

(Baldwin et al., 2016)

The larval crawling defects characteristic for TBPH^Δ23/+ third instar larvae are significantly improved by expressing Rab11^{N124I.Scer\UAS} under the Scer\GAL4^VGlut.PD driver in the mutant background.

(Deshpande et al., 2016)

Expression of Eaat1^{Scer\UAS.Exel} under the control of Scer\GAL4^repo.PU in glia suppresses the motility defects observed in TBPH^Δ23 mutant larvae.

(Romano et al., 2015)

Co-expression of Hrb98DE^JF01249 enhances the climbing defects, shortened life span and neuropil degeneration seen in TBPH^Δ23/+ flies expressing TBPH^GD6943 under the control of Scer\GAL4^elav.PU.

Expression of TBPH^GD6943 under the control of Scer\GAL4^elav.PU enhances the climbing defects, shortened life span and neuropil degeneration seen in TBPH^Δ23/+ flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU.

TBPH^Δ23/+ enhances the climbing defects and shortened life span seen in flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU.

Flies expressing Hrb98DE^JF01249 under the control of Scer\GAL4^elav.PU in a TBPH^Δ23/+ background exhibit degeneration of the neuropil.

(Romano et al., 2014)

Expression of Syx1A^Scer\UAS.cBa under the control of Scer\GAL4^elav.PU rescues the locomotive defects seen in TBPH^Δ23 mutant third instar larvae. The synaptic defects are also rescued. However, the expression of Syx1A^Scer\UAS.cBa under the control of Scer\GAL4^elav.PU is not sufficient to rescue the pupal lethality associated with TBPH^Δ23.

Expression of Syx1A^Scer\UAS.cBa significantly suppresses the climbing defects seen in adult hypomorphic TBPH mutants (generated by expressing TBPH^GD6943 in adult flies under the control of Scer\GAL4^tub.PU and Scer\GAL80^ts.αTub84B, in a TBPH^Δ23/+ background).

(Romano et al., 2014)

Expression of Map205^GD8458 under the control of Scer\GAL4^nSyb.PU suppresses the late pupal lethality seen in TBPH^Δ142/TBPH^Δ23 mutants.

(Vanden Broeck et al., 2013)

One copy of futsch^N94 prevents expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU from rescuing the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. futsch^N94/+ also prevents TBPH^{Scer\UAS.T:Zzzz\FLAG} from restoring microtubule stability in the TBPH^Δ23 mutant flies.

(Godena et al., 2011)

Neuronal overexpression of caz^{Scer\UAS.x10.T:Zzzz\FLAG} under the control of Scer\GAL4^elav-C155 in TBPH^Δ23/Df(2R)BSC660 mutants restores their eclosion rate and longevity to levels not significantly different from that of wild-type animals.

Although overexpression of caz^{Scer\UAS.x10.T:Zzzz\FLAG} under the control of Scer\GAL4^elav-C155 in TBPH^Δ23/Df(2R)BSC660 mutants significantly improves their locomotion velocity, these animals are still significantly slower than controls.

The level of NMJ expansion induced by the overexpression of caz^{Scer\UAS.x10.T:Zzzz\FLAG} via Scer\GAL4^Rapgap1-OK6 is not affected by TBPH^Δ23/Df(2R)BSC660.

(Wang et al., 2011)

Xenogenetic Interactions

Statement

Reference

The semi-lethality and the decreased third instar larval crawling capacity, but not the decreased adult climbing capacity, observed in TBPH¹/TBPH^Δ23 transheterozygotes are suppressed by the expression of either Hsap\TARDBP^{Scer\UAS.x10.T:Zzzz\FLAG} or Hsap\TARDBP^{M337V.Scer\UAS.x10.T:Zzzz\FLAG} under the control of Scer\GAL4^CCAP.PI. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also suppressed by the expression of either Hsap\TARDBP^{Scer\UAS.x10.T:Zzzz\FLAG} or Hsap\TARDBP^{M337V.Scer\UAS.x10.T:Zzzz\FLAG} under the control of Scer\GAL4^CCAP.PI.

(Baldwin et al., 2016)

Scer\GAL4^repo.PU>Hsap\TARDBP^{Scer\UAS.T:Zzzz\FLAG}-expression partially rescues the locomotory defects in TBPH^Δ23 mutants.

(Romano et al., 2015)

Expression of Hsap\TARDBP^{G287S.Scer\UAS.cVBa}, Hsap\TARDBP^{A315T.Scer\UAS.cVBa}, Hsap\TARDBP^{D169G.Scer\UAS.cVBa}, Hsap\TARDBP^{A90V.Scer\UAS.cVBa} or Hsap\TARDBP^{Scer\UAS.cVBa} driven by Scer\GAL4^nSyb.PU equally partially rescue pupal lethality (around 50% of flies expected by a full rescue eclose) in TBPH^Δ142/TBPH^Δ23 mutants. However, the median lifespan of surviving TBPH^Δ142/TBPH^Δ23 flies with expression of Hsap\TARDBP^{A90V.Scer\UAS.cVBa}, Hsap\TARDBP^{A315T.Scer\UAS.cVBa} or Hsap\TARDBP^{G287S.Scer\UAS.cVBa} is significantly lower than flies with expression of Hsap\TARDBP^{D169G.Scer\UAS.cVBa} or Hsap\TARDBP^{Scer\UAS.cVBa} (driven by Scer\GAL4^nSyb.PU); all genotypes display shorter lifespan than controls. Expression (driven by Scer\GAL4^nSyb.PU) of Hsap\TARDBP^{D169G.Scer\UAS.cVBa} or Hsap\TARDBP^{Scer\UAS.cVBa} (but not Hsap\TARDBP^{A90V.Scer\UAS.cVBa}, Hsap\TARDBP^{A315T.Scer\UAS.cVBa} or Hsap\TARDBP^{G287S.Scer\UAS.cVBa}) suppresses the loss of bursicon neurons seen in TBPH^Δ142/TBPH^Δ23 mutants.

(Vanden Broeck et al., 2015)

Expression of Hsap\MAPT^Scer\UAS.cWa in neurons under the control of Scer\GAL4^elav.PU significantly rescues the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The rescued boutons are round with a smooth outline and beaded appearance like wild type controls. The lack of microtubule stability in distal presynaptic structures is also rescued by Hsap\MAPT^Scer\UAS.cWa. However, pan-neuronal expression of Hsap\MAPT^Scer\UAS.cWa is not able to rescue the larval motility defects seen in TBPH^Δ23.

(Godena et al., 2011)

Neuronal expression of Hsap\TARDBP^{Scer\UAS.x10.T:Zzzz\FLAG} under the control of Scer\GAL4^elav-C155 completely suppresses the locomotory, life span and viability defects in TBPH^Δ23/Df(2R)BSC660 mutants.

(Wang et al., 2011)

Expression of Hsap\TARDBP^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 partially rescues the reduced lifespan of TBPH^Δ23 flies.

Expression of Hsap\TARDBP^{Scer\UAS.T:Zzzz\FLAG} under the control of either Scer\GAL4^elav.PLu or Scer\GAL4^D42 rescues the walking and climbing defects of TBPH^Δ23 flies.

The reduced number of synaptic branches and of type 1s and 1b boutons which are seen at the neuromuscular junction of muscles 6 and 7 in TBPH^Δ23 larvae are rescued by expression of Hsap\TARDBP^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42.

(Feiguin et al., 2009)

Complementation and Rescue Data

Rescued by

TBPH^Δ23 is rescued by TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Godena et al., 2011)

TBPH^Δ23 is rescued by Scer\GAL4^elav.PU/TBPH^UAS.Tag:FLAG

(Godena et al., 2011)

Df(2R)BSC660/TBPH^Δ23 is rescued by TBPH^{UAS.10x.Venus}

(Wang et al., 2011)

Partially rescued by

TBPH¹/TBPH^Δ23 is partially rescued by Scer\GAL4^Toll-6-D42/TBPH^{UAS.10x.Venus}

(Baldwin et al., 2016)

TBPH¹/TBPH^Δ23 is partially rescued by Scer\GAL4^CCAP.PU/TBPH^{UAS.10x.Venus}

(Baldwin et al., 2016)

TBPH^Δ23 is partially rescued by Scer\GAL4^repo.PU/TBPH^UAS.Tag:FLAG

(Romano et al., 2015)

TBPH^Δ23 is partially rescued by Scer\GAL4^{elav.Switch.PO}/TBPH^UAS.Tag:FLAG

(Romano et al., 2014)

TBPH^Δ23 is partially rescued by TBPH^{F-L150-152.UAS}/Scer\GAL4^Toll-6-D42

(Godena et al., 2011)

TBPH^Δ23 is partially rescued by TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42

(Feiguin et al., 2009)

Not rescued by

TBPH^Δ23 is not rescued by Scer\GAL4^repo.PU/TBPH^{FL.5x.UAS.Tag:FLAG}

(Romano et al., 2015)

TBPH^Δ23 is not rescued by Scer\GAL4^{elav.Switch.PO}/TBPH^{F-L150-152.UAS}

(Romano et al., 2014)

Comments

The semi-lethality and the decreased third instar larval crawling capacity, but not the decreased adult climbing capacity, observed in TBPH¹/TBPH^Δ23 transheterozygotes are rescued by the expression of TBPH^{Scer\UAS.10x.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^Toll-6-D42. The decreased axonal transport of mitochondria in their third instar larval motor neurons is also partially rescued by the expression of TBPH^{Scer\UAS.10x.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^CCAP.PI.

(Baldwin et al., 2016)

Glial expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^repo.PU significantly rescued the morphological defects in glial shape, the alterations in locomotive behavior and the life span reduction associated with TBPH^Δ23 from larval stages to adulthood.

(Romano et al., 2015)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^{elav.Switch.PO} (fed 0.05 or 0.25ul RU486 throughout the larval stages) is sufficient to rescue the larval locomotion, NMJ growth and cytoskeletal defects in synaptic boutons seen in TBPH^Δ23 mutants. No rescue is seen when the flies are fed low doses of RU486 of ethanol. When expression is restricted to either 48 or 72 hours after egg laying the larval locomotion and NMJ assembly is not rescued at the third instar larval stage. Rescue can occur when drug treatment ends 12 hours prior to measurement.

(Romano et al., 2014)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 significantly rescues the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The lack of stable microtubules in TBPH^Δ23 mutant distal boutons is also rescued.

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU significantly rescues the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The lack of stable microtubules in TBPH^Δ23 mutant distal boutons is also rescued.

Expression of TBPH^{F-L150-152.Scer\UAS} under the control of Scer\GAL4^D42 fails to rescue the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The defects in microtubule stability are also not rescued. Fly motility, including larval movement, adult flies walking and climbing, is partially rescued.

(Godena et al., 2011)

Neuronal expression of TBPH^{Scer\UAS.10x.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^elav-C155 fully rescues the locomotory defects, reduced viability and longevity phenotypes of TBPH^Δ23/Df(2R)BSC660 mutants.

(Wang et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

93599

w^*; TBPH^Δ23/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

TBPH^D23

(Godena et al., 2011)

TBPH^Δ23

(Ervilha Pereira et al., 2023, Strah et al., 2020, Cacciottolo et al., 2019, Mallik et al., 2018, Hosaka et al., 2017, Baldwin et al., 2016, Langellotti et al., 2016, Cragnaz et al., 2015, Vanden Broeck et al., 2015, Llamusi et al., 2013, Zhan et al., 2013, Feiguin et al., 2009)

TBPHΔ23

(Donde et al., 2020, Donde et al., 2019)

dTDP-43^Δ23

(Vanden Broeck et al., 2013)

tbph^Δ23

(Romano et al., 2021, Romano et al., 2018, Appocher et al., 2017, Deshpande et al., 2016, Romano et al., 2015, Miskiewicz et al., 2014, Romano et al., 2014, Romano et al., 2014, Wang et al., 2011)

tbphΔ23

(Langellotti et al., 2018)

Δ23

(Hazelett et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (27)

Report Sections

Open Close