FlyBase Allele Report: Dmel\TBPH[UAS.Tag:FLAG]

General Information

Symbol

Dmel\TBPH^UAS.Tag:FLAG

Species

D. melanogaster

Name

FlyBase ID

FBal0221490

Feature type

allele

Associated gene

Dmel\TBPH

Associated Insertion(s)

Carried in Construct

P{UAS-TBPH.Flag}

Also Known As

UAS-TBPH, UAS-TBPH-FLAG

Key Links

Transgenic product class

wild_type

(Feiguin et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Feiguin et al., 2009)

Mutagen

in vitro construct

(Feiguin et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-TBPH.Flag}

Cytology

Description

UAS regulatory sequences drive expression of TBPH which is tagged with Tag:FLAG.

(Feiguin et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TBPH

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Appocher et al., 2017)

model of amyotrophic lateral sclerosis type 10

CEA

(Farrugia et al., 2022)

CEC

(Ikeda et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegenerative disease

is ameliorated by Hrb27C^GD6964

(Appocher et al., 2017)

is ameliorated by Hrb27C^KK109074

(Appocher et al., 2017)

is ameliorated by CG42458^GD16040

(Appocher et al., 2017)

is ameliorated by CG42458^KK113285

(Appocher et al., 2017)

is ameliorated by glo^GD12082

(Appocher et al., 2017)

is ameliorated by glo^KK108457

(Appocher et al., 2017)

is ameliorated by Syp^GD9477

(Appocher et al., 2017)

is ameliorated by Syp^KK108062

(Appocher et al., 2017)

is ameliorated by Hrb98DE^JF01249

(Appocher et al., 2017)

model of amyotrophic lateral sclerosis type 10

is exacerbated by Chchd2^null

(Ikeda et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PU

(Appocher et al., 2017)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Romano et al., 2014)

abnormal neuroanatomy | adult stage, with Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

decreased rate of adult locomotory behavior, with Scer\GAL4^Toll-6-D42

(Ikeda et al., 2024)

lethal - all die during pupal stage | heat sensitive, with Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

lethal - all die during pupal stage | heat sensitive, with Scer\GAL4^elav-C155

(Vanden Broeck et al., 2013)

lethal - all die during pupal stage | heat sensitive, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

melanotic mass phenotype | adult stage, with Scer\GAL4^GMR.PU

(Appocher et al., 2017)

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PU

(Langellotti et al., 2016)

visible, with Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

visible, with Scer\GAL4^elav-C155

(Vanden Broeck et al., 2013)

visible, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

visible, with Scer\GAL4^Toll-6-D42

(Vanden Broeck et al., 2013)

visible | adult stage, with Scer\GAL4^GMR.PU

(Appocher et al., 2017, Langellotti et al., 2016)

visible | adult stage | female, with Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

Phenotype Manifest In

adult cuticle, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

eye, with Scer\GAL4^GMR.PU

(Appocher et al., 2017, Langellotti et al., 2016)

eye | female, with Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Appocher et al., 2017)

peptidergic neuron, with Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

ptilinum, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

scutellar bristle, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

thorax | dorsal, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

wing, with Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

wing, with Scer\GAL4^elav-C155

(Vanden Broeck et al., 2013)

wing, with Scer\GAL4^nSyb.PU

(Vanden Broeck et al., 2013)

wing, with Scer\GAL4^Toll-6-D42

(Vanden Broeck et al., 2013)

Detailed Description

Statement

Reference

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU leads to eye degeneration in adult flies with loss of pigmentation, dark melanotic spots and ommatidial fusion.

(Appocher et al., 2017)

Adult flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU show large necrotic patches in the eyes.

(Langellotti et al., 2016)

Flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU, restricted to the adult stage using Scer\GAL80^ts.αTub84B, exhibit serious climbing defects compared to controls.

(Romano et al., 2014)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} in the nervous system under the control of Scer\GAL4^nSyb.PU results in temperature dependent lethality. At lower temperatures, immature-looking escapers are seen with unexpanded wings, soft cuticle, unretracted ptilinum, a dimpled dorsal thorax and misoriented scutellar bristles. Lethality at high temperatures and wing phenotypes are also seen with Scer\GAL4^elav-C155 and when TBPH^{Scer\UAS.T:Zzzz\FLAG} is expressed in the motor neurons under the control of Scer\GAL4^D42. Temperature-dependent lethality and a mild wing inflation phenotype is also seen when TBPH^{Scer\UAS.T:Zzzz\FLAG} is expressed in CCAP/bursicon neurons under the control of Scer\GAL4^CCAP.PP.

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^CCAP.PP has no effect on the morphology or number of CCAP neurons in third instar larvae or pupae up to 60 hours after puparium formation. Outgrowth of adult neurites is normal at 60 hours APF. However, at 72h APF and in newly eclosed adults, the number of CCAP/bursicon neurons is reduced.

(Vanden Broeck et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage | female phenotype, enhanceable by Pink1^B9/Pink1^B9

(Ikeda et al., 2024)

Scer\GAL4^Toll-6-D42, TBPH^UAS.Tag:FLAG has decreased rate of adult locomotory behavior phenotype, enhanceable by Chchd2^null/Chchd2^null

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, enhanceable by CG30122^KK100713, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, enhanceable by CG30122^KK100713, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, enhanceable by sqd^GD8593/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, enhanceable by sqd^GD8593/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, enhanceable by HnRNP-K^GD1382, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, enhanceable by HnRNP-K^GD1382, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage | female phenotype, non-enhanceable by Hsap\CHCHD2^WT.UAS, Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, non-enhanceable by HnRNP-K^KK106619, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, non-enhanceable by HnRNP-K^KK106619, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by rump^GD14202/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by rump^GD14202/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by rump^GD14202/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by heph^GD10126/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by heph^GD10126/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by heph^GD10126/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by heph^KK108057/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by heph^KK108057/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by heph^KK108057/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by sm^GD12545/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by sm^GD12545/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by sm^GD12545/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by sm^KK108588/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by sm^KK108588/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by sm^KK108588/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Hrb87F^KK108162, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Hrb87F^KK108162, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Hrb87F^KK108162, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Hrb27C^KK109074, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Hrb27C^KK109074, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Hrb27C^KK109074, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by CG42458^GD16040, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by CG42458^GD16040, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by CG42458^GD16040, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by CG42458^KK113285, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by CG42458^KK113285, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by CG42458^KK113285, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by glo^GD12082/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by glo^GD12082/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by glo^GD12082/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by glo^KK108457/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by glo^KK108457/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by glo^KK108457/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Syp^GD9477/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Syp^GD9477/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Syp^GD9477/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Syp^KK108062/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Syp^KK108062/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Syp^KK108062/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, suppressible | partially by Hrb98DE^JF01249, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, suppressible | partially by Hrb98DE^JF01249, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, suppressible | partially by Hrb98DE^JF01249, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has abnormal neuroanatomy | adult stage phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has abnormal neuroanatomy | adult stage phenotype, suppressible by Map205^GD8458, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has visible phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has abnormal neuroanatomy | adult stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has visible phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | female | adult stage phenotype, non-suppressible by Hsap\CHCHD2^WT.UAS, Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | adult stage phenotype, non-suppressible by rump^KK102889/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has melanotic mass phenotype | adult stage phenotype, non-suppressible by rump^KK102889/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has abnormal eye color phenotype, non-suppressible by rump^KK102889/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Enhancer of

Statement

Reference

TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42 is an enhancer of short lived phenotype of Chchd2^null

(Ikeda et al., 2024)

Other

Statement

Reference

Chchd2^null, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | male | adult stage phenotype

(Ikeda et al., 2024)

Chchd2^null, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has lethal - all die before end of P-stage | female phenotype

(Ikeda et al., 2024)

Pink1^B9, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has visible | male | adult stage phenotype

(Ikeda et al., 2024)

Hsap\CHCHD2^P14L.UAS, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has lethal phenotype

(Ikeda et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye | female phenotype, enhanceable by Pink1^B9/Pink1^B9

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, enhanceable by sqd^GD8593/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, enhanceable by sqd^GD8593/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, enhanceable by CG30122^KK100713, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, enhanceable by CG30122^KK100713, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, enhanceable by HnRNP-K^GD1382, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, enhanceable by HnRNP-K^GD1382, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye | female phenotype, non-enhanceable by Hsap\CHCHD2^WT.UAS, Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, non-enhanceable by HnRNP-K^KK106619, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, non-enhanceable by HnRNP-K^KK106619, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by rump^GD14202/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by rump^GD14202/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by heph^GD10126/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by heph^GD10126/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by heph^KK108057/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by heph^KK108057/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by sm^GD12545/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by sm^GD12545/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by sm^KK108588/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by sm^KK108588/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Hrb87F^KK108162, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Hrb87F^KK108162, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Hrb27C^KK109074, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Hrb27C^KK109074, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by CG42458^GD16040, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by CG42458^GD16040, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by CG42458^KK113285, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by CG42458^KK113285, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by glo^GD12082/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by glo^GD12082/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by glo^KK108457/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by glo^KK108457/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Syp^GD9477/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Syp^GD9477/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Syp^KK108062/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Syp^KK108062/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, suppressible | partially by Hrb98DE^JF01249, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, suppressible | partially by Hrb98DE^JF01249, Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has peptidergic neuron phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has wing phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has peptidergic neuron phenotype, suppressible by Map205^GD8458, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has peptidergic neuron phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

Scer\GAL4^CCAP.PP, TBPH^UAS.Tag:FLAG has wing phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^CCAP.PP

(Vanden Broeck et al., 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye | female phenotype, non-suppressible by Hsap\CHCHD2^WT.UAS, Scer\GAL4^GMR.PU

(Ikeda et al., 2024)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye phenotype, non-suppressible by rump^KK102889/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has ommatidium | adult stage phenotype, non-suppressible by rump^KK102889/Scer\GAL4^GMR.PU

(Appocher et al., 2017)

NOT Suppressor of

Statement

Reference

futsch^N94, Scer\GAL4^elav.PU, futsch[+], TBPH^UAS.Tag:FLAG is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of TBPH^Δ23

(Godena et al., 2011)

futsch^N94, Scer\GAL4^elav.PU, futsch[+], TBPH^UAS.Tag:FLAG is a non-suppressor of NMJ bouton | third instar larval stage phenotype of TBPH^Δ23

(Godena et al., 2011)

futsch^N94, Scer\GAL4^elav.PU, futsch[+], TBPH^UAS.Tag:FLAG is a non-suppressor of microtubule | third instar larval stage phenotype of TBPH^Δ23

(Godena et al., 2011)

Other

Statement

Reference

Chchd2^null, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye | male phenotype

(Ikeda et al., 2024)

Pink1^B9, Scer\GAL4^GMR.PU, TBPH^UAS.Tag:FLAG has eye | male phenotype

(Ikeda et al., 2024)

Chchd2^null, Scer\GAL4^Toll-6-D42, TBPH^UAS.Tag:FLAG has mitochondrion phenotype

(Ikeda et al., 2024)

Chchd2^null, Scer\GAL4^Toll-6-D42, TBPH^UAS.Tag:FLAG has motor neuron phenotype

(Ikeda et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

The eye degeneration phenotype (appearance of melanotic spots, fusion of ommatidia) characteristic for adult flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU is exacerbated further by co-expression of any of the following: CG30122^KK100713, HnRNP-K^GD1382 or sqd^GD8593 and suppressed (to a varying degree) by co-expression of: rump^GD14202, heph^GD10126, heph^KK108057, sm^GD12545, sm^KK108588, Hrb87F^KK108162, Hrb27C^GD6964, Hrb27C^KK109074, CG42458^GD16040, CG42458^KK113285, glo^GD12082, glo^KK108457, Syp^GD9477, Syp^KK108062 or Hrb98DE^JF01249; co-expression of either HnRNP-K^KK106619 or rump^KK102889 has no significant effect on the eye phenotype.

(Appocher et al., 2017)

Expression of Diap1^Scer\UAS.cHa suppresses the reduction in CCAP/bursicon neuron number seen in newly eclosed flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^CCAP.PP. The wing inflation defects are also rescued.

Expression of Map205^GD8458 suppresses the immature wing inflation phenotype seen when TBPH^{Scer\UAS.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^nSyb.PU.

Expression of Map205^GD8458 suppresses the wing inflation phenotype and loss of CCAP/bursicon neurons seen when TBPH^{Scer\UAS.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^CCAP.PP.

(Vanden Broeck et al., 2013)

One copy of futsch^N94 prevents expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU from rescuing the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. futsch^N94/+ also prevents TBPH^{Scer\UAS.T:Zzzz\FLAG} from restoring microtubule stability in the TBPH^Δ23 mutant flies.

(Godena et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa suppresses the reduction in CCAP/bursicon neuron number seen in newly eclosed flies expressing TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^CCAP.PP. The wing inflation defects are also rescued.

(Vanden Broeck et al., 2013)

Complementation and Rescue Data

Rescues

TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42 rescues TBPH^Δ23

(Godena et al., 2011)

Scer\GAL4^elav.PU/TBPH^UAS.Tag:FLAG rescues TBPH^Δ23

(Godena et al., 2011)

TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42 rescues TBPH^Δ142

(Godena et al., 2011)

Partially rescues

Scer\GAL4^repo.PU/TBPH^UAS.Tag:FLAG partially rescues TBPH^Δ23

(Romano et al., 2015)

Scer\GAL4^{elav.Switch.PO}/TBPH^UAS.Tag:FLAG partially rescues TBPH^Δ23

(Romano et al., 2014)

TBPH^UAS.Tag:FLAG/Scer\GAL4^Toll-6-D42 partially rescues TBPH^Δ23

(Feiguin et al., 2009)

Comments

Glial expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^repo.PU significantly rescued the morphological defects in glial shape, the alterations in locomotive behavior and the life span reduction associated with TBPH^Δ23 from larval stages to adulthood.

(Romano et al., 2015)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^{elav.Switch.PO} (fed 0.05 or 0.25ul RU486 throughout the larval stages) is sufficient to rescue the larval locomotion, NMJ growth and cytoskeletal defects in synaptic boutons seen in TBPH^Δ23 mutants. No rescue is seen when the flies are fed low doses of RU486 of ethanol. When expression is restricted to either 48 or 72 hours after egg laying the larval locomotion and NMJ assembly is not rescued at the third instar larval stage. Rescue can occur when drug treatment ends 12 hours prior to measurement. 12 hours of RU486 treatment in mature third instar larval stages until the end of the larval period is sufficient to restore normal locomotive behaviors compared to controls. The NMJs in these larvae show a clear re-elaboration of motoneuron terminals with the formation of new synaptic branches and the addition of new synaptic boutons. Feeding newly eclosed flies RU486 results in robust rescue of climbing ability in TBPH^Δ23 mutant flies.

(Romano et al., 2014)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 significantly rescues the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The lack of stable microtubules in TBPH^Δ23 mutant distal boutons is also rescued.

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 rescues the defects in microtubule stability seen in TBPH^Δ142 mutant distal boutons.

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU significantly rescues the reduction in bouton number and terminal branches seen in muscles 6 and 7 of homozygous TBPH^Δ23 third instar larvae. The lack of stable microtubules in TBPH^Δ23 mutant distal boutons is also rescued.

(Godena et al., 2011)

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 partially rescues the reduced lifespan of TBPH^Δ23 flies.

Expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42 rescues the walking and climbing defects of TBPH^Δ23 flies.

The reduced number of synaptic branches and of type 1s and 1b boutons which are seen at the neuromuscular junction of muscles 6 and 7 in TBPH^Δ23 larvae are rescued by expression of TBPH^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42.

(Feiguin et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

93601

w^*; P{UAS-TBPH.Flag}1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

TBPH^{Scer\UAS.T:Zzzz\FLAG}

TBPH^UAS.Tag:FLAG

Name Synonyms

Secondary FlyBase IDs

References (14)

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