Allele Dmel\snRNA:U7^EY11305

General Information
Symbol	Dmel\snRNA:U7^EY11305	Species	D. melanogaster
Name		FlyBase ID	FBal0221516
Feature type	allele	Associated gene	Dmel\snRNA:U7
Also Known As	U7^EY11305

Map ( GBrowse )	Untitled Document
Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:3,593,858..3,593,858 (Godfrey et al., 2006, Ezzeddine et al., 2011)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion located 8bp downstream of the Sm protein binding site between nucleotides 34 and 44 of the snRNA:U7 RNA. (Godfrey et al., 2006)
Caused by insertion	P{EPgy2}snRNA:U7^EY11305 (Godfrey et al., 2006, Ezzeddine et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (with Df(3L)GN50) (Godfrey et al., 2006) female sterile \| recessive (Godfrey et al., 2006) male sterile (with Df(3L)GN50) (Godfrey et al., 2006) male sterile \| recessive (Godfrey et al., 2006) viable (Godfrey et al., 2006) viable (with Df(3L)GN50) (Godfrey et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	snRNA:U7¹⁴/snRNA:U7^EY11305 is rescued by snRNA:U7^+tGa (Godfrey et al., 2006)
Comments
Stocks ( 1 )
Bloomington	20288 y¹ w^67c23; P{EPgy2}snRNA:U7^EY11305
Notes on Origin
Discoverer

Comments
	Precise excision of the insertion restores male and female fertility. (Godfrey et al., 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	snRNA:U7^EY11305 U7^EY11305 (Wagner et al., 2007, Godfrey et al., 2006, Godfrey et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Ezzeddine et al., 2011, Mol. Cell. Biol. 31(2): 328--341 A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation. [FBrf0212592] Godfrey et al., 2009, RNA 15(9): 1661--1672 The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. [FBrf0208608] Wagner et al., 2007, Mol. Cell 28(4): 692--699 A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. [FBrf0201575] Godfrey et al., 2006, RNA 12(3): 396--409 U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis. [FBrf0190593]

Allele Dmel\snRNA:U7EY11305

Allele Dmel\snRNA:U7^EY11305