FlyBase Allele Report: Dmel\APP-BP1[UAS.cKa]

General Information

Symbol

Dmel\APP-BP1^UAS.cKa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Kim

FlyBase ID

FBal0221556

Feature type

allele

Associated gene

Dmel\APP-BP1

Associated Insertion(s)

Carried in Construct

P{UAS-APP-BP1.K}

Key Links

Transgenic product class

cDNA

(Kim et al., 2007)

wild_type

(Kim et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Kim et al., 2007)

wild_type

(Kim et al., 2007)

Mutagen

in vitro construct

(Kim et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-APP-BP1.K}

Cytology

Description

UASt regulatory sequences drive expression a full-length APP-BP1 cDNA.

(Kim et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

APP-BP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^RNAi.UAS.cWa

(Choo et al., 2012)

modeled by Pink1^RNAi.UAS.cYa

(Choo et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Kim et al., 2007)

visible, with Scer\GAL4^how-24B

(Choo et al., 2012)

Phenotype Manifest In

scutellar bristle, with Scer\GAL4^ap-md544

(Kim et al., 2007)

scutellum, with Scer\GAL4^ap-md544

(Kim et al., 2007)

wing, with Scer\GAL4^how-24B

(Choo et al., 2012)

Detailed Description

Statement

Reference

Expression of APP-BP1^Scer\UAS.cKa under the control of Scer\GAL4^how-24B results in a drooped wing phenotype.

(Choo et al., 2012)

Expression of APP-BP1^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 results in a decrease in the size of the scutellum and most of the scutellar macrochaetae are missing.

Expression of APP-BP1^Scer\UAS.cKa under the control of Scer\GAL4^Bx-MS1096 has no effect on the size of the wing.

(Kim et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Mhc.PW/APP-BP1^UAS.cKa is a suppressor | partially of male semi-sterile phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU

(Choo et al., 2012)

APP-BP1^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pink1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Choo et al., 2012)

APP-BP1^UAS.cKa, Scer\GAL4^Mhc.PW is a suppressor of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Choo et al., 2012)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a suppressor of visible phenotype of Appl^sd.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a suppressor of increased cell death phenotype of Appl^sd.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

NOT Suppressor of

Statement

Reference

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a non-suppressor of visible phenotype of Appl^sdΔIC.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a non-suppressor of increased cell death phenotype of Appl^sdΔIC.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

APP-BP1^UAS.cKa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pink1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Choo et al., 2012)

APP-BP1^UAS.cKa, Scer\GAL4^Mhc.PW is a suppressor of eye phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Choo et al., 2012)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a suppressor of wing phenotype of Appl^sd.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a suppressor of wing pouch phenotype of Appl^sd.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

NOT Suppressor of

Statement

Reference

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a non-suppressor of wing phenotype of Appl^sdΔIC.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

APP-BP1^UAS.cKa, Scer\GAL4^Bx-MS1096 is a non-suppressor of wing pouch phenotype of Appl^sdΔIC.UAS, Scer\GAL4^Bx-MS1096

(Kim et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of APP-BP1^Scer\UAS.cKa partially suppresses the eye phenotype seen when Pink1^{dsRNA.Scer\UAS.cWa} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of APP-BP1^Scer\UAS.cKa partially suppresses the drooped wing phenotype seen when Pink1^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^Mhc.PW.

(Choo et al., 2012)

The wing phenotypes caused by expression of Appl^sd.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 are suppressed by co-expression of APP-BP1^Scer\UAS.cKa.

The wing phenotypes caused by expression of Appl^{sd.ΔIC.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 are not suppressed by co-expression of APP-BP1^Scer\UAS.cKa.

The increased cell death seen in the wing discs of animals expressing Appl^sd.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is suppressed by co-expression of APP-BP1^Scer\UAS.cKa.

The increased cell death seen in the wing discs of animals expressing Appl^{sd.ΔIC.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 is not suppressed by co-expression of APP-BP1^Scer\UAS.cKa.

The increased cell death seen in the wing discs of animals expressing Appl^sd.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is enhanced by APP-BP1^Ex62/+.

(Kim et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

APP-BP1^Scer\UAS.cKa

APP-BP1^UAS.cKa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Kim

Secondary FlyBase IDs

References (2)

Report Sections

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