FB2025_01 , released February 20, 2025
Allele: Dmel\Xrp1Exel6181
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General Information
Symbol
Dmel\Xrp1Exel6181
Species
D. melanogaster
Name
FlyBase ID
FBal0221558
Feature type
allele
Associated gene
Dmel\Xrp1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    P{XP}d06938
    (Akdemir et al., 2007)
    Caused by aberration
    Df(3R)Exel6181
    Cytology
    Description

    Deletion breakpoint within intron 3. The deletion extends proximally from the progenitor P{XP}d06938 insertion site in intron 3, removing Xrp1 sequences upstream of the insertion site.

    (Akdemir et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Xrp1Exel6181/Xrp1Exel6182 show significantly higher rates of loss-of-heterozygosity after irradiation compared to control animals. Mutant larval wing discs show apoptosis and cell cycle arrest after irradiation, as occurs in wild-type discs.

        (Akdemir et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Xrp1Exel6181
        Name Synonyms
        Secondary FlyBase IDs
          References (1)