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General Information
Symbol
Dmel\TrpmlUAS.cVa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Venkatachalam
FlyBase ID
FBal0221785
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-trpml
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a Trpml cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The late pupal lethality observed in animals expressing AMPKαJF01951 under the control of Scer\GAL4tub.PU cannot be rescued by co-expression of TrpmlScer\UAS.cVa.

The pupal-stage lethality of either hemizygous AMPKα1 or AMPKα3 males cannot be rescued by expression of TrpmlScer\UAS.cVa under the control of Scer\GAL4tub.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Ectopic expression of TrpmlScer\UAS.cVa using either the Scer\GAL4elav-C155 or the Scer\GAL4C164 driver (but not the Scer\GAL4Mef2.PR driver) rescues the loss of neuromuscular junction boutons characteristic for Trpml1 mutant third instar larvae.

Expression of trpmlScer\UAS.cVa under the control of Scer\GAL4repo partially rescues the lethality of trpml1 animals. The climbing ability of trpml1 animals is significantly rescued, but there is still some age-dependent decline in climbing ability in the rescued animals. The defects in excitatory junctional potential amplitude

of trpml1 larvae are also rescued. The accumulation of late apoptotic/necrotic cells that is seen in 21 day old trpml1 adult brains is rescued, but the accumulation of early apoptotic cells in these brains is not rescued.

Expression of trpmlScer\UAS.cVa under the control of Scer\GAL4Cg.PA rescues the lethality of trpml1 animals. The climbing ability of trpml1 animals is significantly rescued, but there is still some age-dependent decline in climbing ability in the rescued animals. The accumulation of late apoptotic/necrotic cells that is seen in 21 day old trpml1 adult brains is rescued, but the accumulation of early apoptotic cells in these brains is not rescued.

Expression of trpmlScer\UAS.cVa under the control of Scer\GAL4c754 rescues the lethality of trpml1 animals. The defects in excitatory junctional potential amplitude

of trpml1 larvae are also rescued.

Expression of trpmlScer\UAS.cVa under the control of Scer\GAL4Hml.PG partially rescues the lethality of trpml1 animals.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
TrpmlScer\UAS.cVa
TrpmlUAS.cVa
trpmlScer\UAS.cVa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Venkatachalam
Secondary FlyBase IDs
    References (4)