FB2025_01 , released February 20, 2025
Allele: Dmel\tweekc01084
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General Information
Symbol
Dmel\tweekc01084
Species
D. melanogaster
Name
FlyBase ID
FBal0222480
Feature type
allele
Associated gene
Dmel\tweek
Associated Insertion(s)
PBac{PB}tweekc01084
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{PB}tweekc01084
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Most tweek1/tweekc01084 and tweek2/tweekc01084 animals die as pharate adults, although a few adult escapers are seen. These adult escapers are severely uncoordinated.

        tweek2/tweekc01084 mutants have a normal excitatory junctional potential amplitude during low-frequency stimulation (< 1Hz).

        tweek2/tweekc01084 mutants show a decline in excitatory junctional potential amplitude to approximately 55-60% of the initial response when stimulated at 10Hz in 5mM Ca[2+] (controls maintain release at about 90% of the initial response after 10 minutes under these conditions).

        tweek2/tweekc01084 animals show a significant reduction of FM1-43 dye uptake at the third larval instar neuromuscular junction compared to controls.

        The amplitude of spontaneous excitatory junctional currents (mEJCs) is increased and the frequency of mEJCs is decreased in tweek2/tweekc01084 animals compared to controls. Quantal content is decreased in tweek2/tweekc01084 animals compared to controls.

        (Verstreken et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Excision of the insertion can revert the lethal phenotype.

        (Verstreken et al., 2009)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG42555c01084
        tweekc01084
        (Verstreken et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)