FlyBase Allele Report: Dmel\Cds[EY08412]

General Information

Symbol

Dmel\Cds^EY08412

Species

D. melanogaster

Name

FlyBase ID

FBal0223839

Feature type

allele

Associated gene

Dmel\Cds

Associated Insertion(s)

P{EPgy2}Cds^EY08412

Carried in Construct

Also Known As

P{EPgy2}CdsA^EY08412

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Cds^EY08412

Cytology

Description

P{EPgy2}CdsA^EY08412 contains Scer\UAS sites which drive expression of CdsA.

(Tian et al., 2011)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:8,128,087..8,128,087 [+]

(Yang et al., 2019, Laurinyecz et al., 2016, Liu et al., 2014, Tian et al., 2011, FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile

(Laurinyecz et al., 2016)

male sterile (with Df(3L)BSC795)

(Laurinyecz et al., 2016)

Phenotype Manifest In

embryonic/larval salivary gland, with Scer\GAL4^ppl.PP

(Liu et al., 2014)

spermatid

(Laurinyecz et al., 2016)

waste bag

(Laurinyecz et al., 2016)

Detailed Description

Statement

Reference

CdsA^EY08412 homozygous male adults as well as CdsA^EY08412/Df(3L)BSC795 are completely sterile but CdsA¹/CdsA^EY08412 males are fertile.

Adult CdsA^EY08412 homozygote mutants have no mature sperm in the seminal vesicles and display spermatid individualization defects: the actin-rich investment cones are established but are disorganized and move asynchronously along the spermatids.

(Laurinyecz et al., 2016)

Expression of CdsA^EY08412, under the control of Scer\GAL4^ppl.PP slightly increases the size of the salivary gland.

Fat body-specific expression of CdsA^EY08412 under the control of either Scer\GAL4^ppl.PP or Scer\GAL4^Cg.PA does not result in a significant lipid storage phenotype in the fat body. Consistent with this, the total glyceride level and fat cell size is not significantly different in these flies compared to controls.

(Liu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cds^EY08412, Scer\GAL4^ppl.PP is a suppressor | partially of decreased cell size phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^ppl.PP

(Liu et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Cds^EY08412, Scer\GAL4^ppl.PP is an enhancer of embryonic/larval salivary gland | third instar larval stage phenotype of Pss^KK105709, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Cds^EY08412, Scer\GAL4^ppl.PP is an enhancer of mitochondrial crista | third instar larval stage phenotype of Pss^KK105709, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Suppressor of

Statement

Reference

Cds^EY08412, Scer\GAL4^ppl.PP is a suppressor of embryonic/larval salivary gland | third instar larval stage phenotype of Pss^KK105709, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Cds^EY08412, Scer\GAL4^ppl.PP is a suppressor of lipid droplet | increased number phenotype of Pss^KK105709, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Cds^EY08412, Scer\GAL4^ppl.PP is a suppressor of embryonic/larval salivary gland phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^ppl.PP

(Liu et al., 2014)

Cds^EY08412/Scer\GAL4^48Y is a suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

Cds^EY08412/Scer\GAL4^48Y is a suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

NOT Suppressor of

Statement

Reference

Cds^EY08412, Scer\GAL4^ppl.PP is a non-suppressor of mitochondrion phenotype of Pss^KK105709, Scer\GAL4^ppl.PP

(Yang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of CdsA^EY08412 partially, but significantly, rescues the small cell size phenotype found in flies expressing Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} (when both are expressed in the salivary gland and fat body, under the control of Scer\GAL4^ppl.PP). Moreover, the salivary gland ectopic lipid storage phenotype found in Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}-expressing flies can be fully suppressed by CdsA^EY08412 overexpression.

(Liu et al., 2014)

The ectopic lipid storage phenotype of Seipin^null mutants is fully suppressed by expressing CdsA^EY08412 using Scer\GAL4^48Y.

(Tian et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

16893

y¹ w^67c23; P{EPgy2}Cds^EY08412

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cds^EY08412

CdsA^EY08412

(Laurinyecz et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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