Expression of all dysc isoforms is reduced but still detectable in dyscc05107 mutants.
dyscc05107 homozygotes display relatively mild arrhythmic locomotor patterns in constant dark conditions, with some animals showing robust rhythmicity.
In 12 h light:dark conditions, anticipation of both lights-on and lights-off is maintained in dyscc05107 flies. Overall daytime and nighttime activity is greater in these mutants compared to wild type in these conditions.
dyscs168/dyscc05107 animals display arrhythmic locomotor patterns in constant dark conditions.
dyscc03838/dyscc05107 animals display arrhythmic locomotor patterns in constant dark conditions.
dyscc07121/dyscc05107 mutant flies show significant indirect flight muscle degeneration compared to controls.
dyscc05107/+ mutant flies do not exhibit temperature-induced mobility defects.
dyscc05107 mutant third instar larvae display a significantly increased frequency of axon migration abnormalities in the brain compared to controls, resulting in defects in the lamina plexus.
DgO86, dyscc05107/dysc[+] has abnormal neuroanatomy | third instar larval stage phenotype
Df(3R)Exel6184/+, dyscc05107 has abnormal neuroanatomy | third instar larval stage phenotype
DgO86, dyscc05107/dysc[+] has lamina plexus | third instar larval stage phenotype
Df(3R)Exel6184/+, dyscc05107 has lamina plexus | third instar larval stage phenotype
Combination of Df(3R)Exel6184 in heterozygous state with a single copy of dyscc05107 results in a significantly increased frequency of lamina plexus defects in the third instar larval brain in the double heterozygotes.
Combination of DgO86 in heterozygous state with a single copy of dyscc05107, results in significantly increased frequency of lamina plexus defects in third instar larvae.
