FB2025_01 , released February 20, 2025
Allele: Dmel\imdNP1182
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General Information
Symbol
Dmel\imdNP1182
Species
D. melanogaster
Name
FlyBase ID
FBal0227095
Feature type
allele
Associated gene
Dmel\imd
Associated Insertion(s)
P{GawB}imdNP1182
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}imdNP1182
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Motor neurons in imdNP1182/imdNP1182 third instar larvae display a small, but statistically significant reduction in active zone density, with a similar number of type I boutons and active zones as controls. They show a similar baseline neurotransmission, with similar quantal content, mEPSP (mini excitatory postsynaptic potential) and EPSP (excitatory postsynaptic potential) amplitudes, mEPSP frequency as controls.

        (Harris et al., 2018)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Motor neurons in imdNP1182, GluRIIASP16 double mutant third instar larvae have reduced mEPSP (mini excitatory postsynaptic potential) compared to single imdNP1182 (but not GluRIIASP16) mutants; reduced EPSP (excitatory postsynaptic potential) amplitudes compared to either single mutant; and reduced quantal content compared to single GluRIIASP16 (but not imdNP1182) mutants. Their capacity for long-term presynaptic homeostatic plasticity (i.e. increase in quantal content causing an increase in EPSP amplitude, approaching baseline) is completely blocked.

        (Harris et al., 2018)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        ImdNP
        (Harris et al., 2018)
        imdNP1182
        (Harris et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)