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General Information
Symbol
Dmel\Sirt1NP1145
Species
D. melanogaster
Name
FlyBase ID
FBal0229276
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    P{GawB}Sirt1NP1145
    Product class / Tool use(s)
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Sirt1NP1145/Sirt1NP1145 flies show strongly reduced conditioned odor preference associated with ethanol intoxication, but no defects in olfactory acuity.

    At 60% ethanol vapor dose, Sir2NP1145 flies show reduced sedation sensitivity, reduced sedation tolerance, and almost no increase in locomotor activity upon repeated ethanol exposure compared to controls. At 73% ethanol vapor dose, Sir2NP1145 flies retain the latter phenotype, but exhibit normal sedation sensitivity and sedation tolerance.

    Sir22A-7-11/Sir2NP1145 flies show almost no increase in locomotor activity upon repeated ethanol exposure compared to controls.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Sir2NP1145
    Sirt1NP1145
    Name Synonyms
    Secondary FlyBase IDs
      References (3)