Allele Dmel\fab1³¹

General Information
Symbol	Dmel\fab1³¹	Species	D. melanogaster
Name		FlyBase ID	FBal0230155
Feature type	allele	Associated gene	Dmel\fab1

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms ethyl methanesulfonate loss of function allele pharate adult stage third instar larval stage lethal endosome imaginal disc large body embryonic/larval garland cell pupal stage
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Rusten et al., 2006)
Mutagen	ethyl methanesulfonate (Rusten et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: L1321@. (Rusten et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	large body \| pupal stage (with Df(2R)14H10W-30) (Rusten et al., 2006) lethal \| pharate adult stage (with Df(2R)14H10W-30) (Rusten et al., 2006) lethal \| pharate adult stage (with fab1⁸) (Rusten et al., 2006) lethal \| pharate adult stage (with fab1²¹) (Rusten et al., 2006)
Phenotype Manifest In
	embryonic/larval garland cell \| third instar larval stage (with Df(2R)14H10W-30) (Rusten et al., 2006) endosome (with Df(2R)14H10W-30) (Rusten et al., 2006) eye disc (with fab1²¹) (Rusten et al., 2007) imaginal disc (with Df(2R)14H10W-30) (Rusten et al., 2006)
Detailed Description
	Statement Reference fab1[31]/Df(2R)14H10W-30 pupae are larger than controls, even though these animals do not have an extended larval phase. Legs dissected from the mutant pharate adults are the correct length but are considerably thicker than normal. The Garland cells of fab1[31]/Df(2R)14H10W-30 wandering third instar larvae are up to 3 times the normal diameter and their endosomes are dramatically enlarged compared to wild type. The imaginal discs of mutant larvae have larger cells than normal and show a disorganised distribution of nuclei relative to wild-type discs, although overall cell polarity is intact. (Rusten et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	fab1³¹ (Rusten et al., 2007, Rusten et al., 2006) l(2)SJB³¹ (Rusten et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Rusten et al., 2007, Curr. Biol. 17(20): 1817--1825 ESCRTs and Fab1 regulate distinct steps of autophagy. [FBrf0201360] Rusten et al., 2006, Mol. Biol. Cell 17(9): 3989--4001 Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. [FBrf0192946]

Allele Dmel\fab131

Allele Dmel\fab1³¹