FB2025_01 , released February 20, 2025
Allele: Dmel\lqfR03685
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General Information
Symbol
Dmel\lqfR03685
Species
D. melanogaster
Name
FlyBase ID
FBal0230310
Feature type
allele
Associated gene
Dmel\lqfR
Associated Insertion(s)
P{PZ}lqfR03685
Carried in Construct
Also Known As
l(3)03685, lqfRP
Key Links
Genomic Maps

Allele class

heat sensitive hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Lee et al., 2009)

hypomorphic allele - molecular evidence

(Lee et al., 2009)
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}lqfR03685
Cytology
Description

Insertion 94bp upstream of the start codon.

(Lee et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18[o]C, homozygous eclose and appear morphologically normal.

      Homozygotes show semi-lethality at 25[o], with most homozygotes dying fully formed in their pupal cases. Adult escapers often have obvious morphological defects; the eyes are kidney-shaped and rough, the wings are notched and the wing hair patterns may suggest planar cell polarity defects. Duplications of the anterior scutellar bristles are also seen.

      The ommatidia near the morphogenetic furrow are abnormally mature in mutant larval eye discs, and the rows of developing ommatidia are V-shaped, rather than straight as in wild-type discs. In adult flies, the eyes are rough along the equator, and the ommatidia in this region have a wide variety of defects, including ommatidia with too many or too few photoreceptors, irregular polarity and ommatidial fusions. Away from the equator, the ommatidia are normal.

      (Lee et al., 2009)

      semi-viable

      (Lee et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      arm3/+ ; lqfR03685/lqfRΔ117 and arm8/+ ; lqfR03685/lqfRΔ117 animals die in the pupal case. They have small or absent eyes, small head capsules and also have morphological defects in the head cuticle, wings and legs.

      wgl-17/+ ; lqfR03685/lqfRΔ117 adult escapers have severely defective eyes, ranging from kidney-shaped to nearly absent. They also have defects in the head cuticle.

      (Lee and Fischer, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: sar105712. Complements: howj5D5. Complements: l(3)rQ178rQ178.

      (BDGP Project Members, 1994-1999)

      Precise excision of the insertion reverts the mutant phenotype.

      (Lee et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      LqfR[P]
      (Lee et al., 2006)
      epsin-like03685
      (Christensen et al., 2008.4.15, Christensen et al., 2008.6.11, Christensen et al., 2008.12.28)
      epsin-likeP
      l(3)03685
      (Leventis et al., 2011, Spradling et al., 1999)
      l(3)0368503685
      lqfR03685
      (Leventis et al., 2011)
      lqfRP3685
      (Lee et al., 2009)
      lqfRP
      (Lee and Fischer, 2012, Lee et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0009480
      • FBal0190451
      References (12)