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General Information
Symbol
Dmel\lsnNN31
Species
D. melanogaster
Name
FlyBase ID
FBal0230472
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vps22NN31
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C21865686T

Reported nucleotide change:

C?T

Amino acid change:

Q137term | lsn-PA

Reported amino acid change:

Q137term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C?T.

Amino acid replacement: Q137term.

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 117 amino acids of the wild-type product.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous lsnNN31 mutant tissue partially survives in mosaic eye discs, and is not completely 'out-competed'. Although mutant ommatidia are not recovered, the wild-type ommatidia composing the adult eyes of mosaic animals are variably overgrown.

Compared with wild-type, egg chambers containing lsnNN31 mutant cells exhibit a loss of plasma membrane, ultimately leading to the formation of clusters of multinucleated cells enclosed by a single actin cytoskeleton, with nuclei rested around clumps of actin-positive structures, possibly also membrane fragments.

lsnNN31 mutant oocytes rarely contain intralumenal vesicles and isolated multivesicular bodies. They also exhibit irregularly shaped yolk granules.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)