Open Close
General Information
Symbol
Dmel\lsnZZ13
Species
D. melanogaster
Name
FlyBase ID
FBal0230475
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G21865535A

Amino acid change:

W86term | lsn-PA

Reported amino acid change:

W86term

Comment:

TGG to TGA nonsense mutation in codon W86@.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Amino acid replacement: W86term.

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 168 amino acids of the wild-type product.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lsnZZ13 mutant clones in the eye disc overproliferate compared to wild type cells.

lsnZZ13 mutant oocytes rarely contain intralumenal vesicles and isolated multivesicular bodies. They also exhibit irregularly shaped yolk granules.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
NOT Suppressor of
Statement
Reference

lsnZZ13 is a non-suppressor of eye disc | somatic clone phenotype of Vha55j2E9

Additional Comments
Genetic Interactions
Statement
Reference

Clones in the eye discs of Vha55j2E9 lsnZZ13 double mutants display the underproliferation phenotype seen in Vha55j2E9 mutant clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)