|Feature type||allele||Associated gene||Dmel\Aats-tyr|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - amino acid replacement|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: E196K.
|Carried in construct|
|Phenotype Manifest In|
Neuronal expression of Aats-tyr[E196K.Scer\UAS] usint Scer\GAL4[n-syb.PS] induces a significant climbing deficit compared with controls. Ubiquitous expression of Aats-tyr[E196K.Scer\UAS] under the control of Scer\GAL4[Act5C.PI] induces significant lethality.
Flies expressing one copy of Aats-tyr[E196K.Scer\UAS] under the control of Scer\GAL4[Act5C] show a severely impaired performance in a negative geotaxis climbing assay compared to controls. Aged flies expressing Aats-tyr[E196K.Scer\UAS] under the control of Scer\GAL4[Act5C] show impairment in both jump and flight ability (92% of aged flies fail to fly and 30% fail to jump). This impairment is progressive, becoming more severe as the flies age. Flies expressing Aats-tyr[E196K.Scer\UAS] under the control of Scer\GAL4[n-syb.PS] show an impaired performance in a negative geotaxis climbing assay compared to controls. Flies expressing two copies of Aats-tyr[E196K.Scer\UAS] under the control of Scer\GAL4[A307] show electrophysiological defects in the giant fiber system. Some flies have normal response latencies but defects in following high frequency stimulation, whereas some flies are more severely affected and have an increased response latency. The severity and frequency of the mutant phenotype increases with age.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 2 )|