FB2025_01 , released February 20, 2025
Allele: Dmel\Rbsn-5C241
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General Information
Symbol
Dmel\Rbsn-5C241
Species
D. melanogaster
Name
FlyBase ID
FBal0230493
Feature type
allele
Associated gene
Dmel\Rbsn-5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tanaka and Nakamura, 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?315term.

(Tanaka and Nakamura, 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,161,093..8,161,093 [+]
Nucleotide change:

T8161093A

Amino acid change:

L315term | Rbsn-5-PA

Reported amino acid change:

?315term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Tanaka and Nakamura, 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oocytes in homozygous female germline clones do not incorporate either auto-fluorescent granules derived from endocytosed yolk proteins or the FM4-64 dye (a marker for endocytosis), in contrast to wild-type oocytes.

      (Tanaka and Nakamura, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Rbsn-5C241/Rbsn-5C241 is an enhancer of filamentous actin & oocyte phenotype of Scer\GAL4VP16.mat.αTub67C, oskbcd.3'UTR.UASp

      (Tanaka and Nakamura, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The fraction of oocytes showing endocytic activity in EndoB54/Rbsn-5C241 double heterozygotes is not reduced compared to either single heterozygote.

      (Tsai et al., 2014)

      Oocytes of homozygous Rbsn-5C241 female germline clones which are also expressing oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show large aberrant F-actin aggregates at the anterior region of the oocyte.

      (Tanaka and Nakamura, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rbsn-5C241 is rescued by Rbsn-5+t4.5

      (Tanaka and Nakamura, 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      C241
      (Tanaka and Nakamura, 2008)
      CG8506C241
      (Tanaka and Nakamura, 2008)
      Rbsn-5C241
      (Vazquez-Pianzola et al., 2014, Abe et al., 2009)
      rbsn-5C241
      (Tsai et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)