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General Information
Symbol
Dmel\EgfrKK100051
Species
D. melanogaster
Name
FlyBase ID
FBal0230558
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Egfr-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of EgfrKK100051 under the control of Scer\GAL4elav.PU leads to more rapid ethanol sedation compared to controls.

Reducing Egfr levels by EgfrKK100051-mediated knockdown in the posterior wing compartment (under the control of Scer\GAL4en-e16E), leads to the loss of the lateral vein L4 and the apical crossvein, along with some growth defects.

Knockdown of Egfr in wing margin cells, through the expression of EgfrKK100051 under the control of Scer\GAL4wg-IS650 and Scer\GAL80ts.αTub84B results in extra apoptosis even at 30 hours after pupal formation. As a result of this apoptosis, some inter-hair cells are lost.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The increased resistance to ethanol-induced sedation characteristic for both DopEcRc02142 and DopEcRGAL4 homozygous adults is significantly suppressed by expression of EgfrKK100051 under the control of the Scer\GAL4elav.PU driver in the DopEcRc02142 background or the intrinsic Scer\GAL4DopEcR-GAL4 driver in the DopEcRGAL4 mutants.

Reducing Egfr levels by EgfrKK100051-mediated knockdown in the posterior wing compartment (under the control of Scer\GAL4en-e16E), in a stepdsRNA.Scer\UAS background generates a more severe Egfr phenotype. The lateral vein L4 is entirely lost, both cross veins are not differentiated and the distal end of the lateral vein L5 is missing.

Expression of stepScer\UAS.FL suppresses the wing vein defects caused by expression of EgfrKK100051 in the posterior compartment of the wing, under the control of Scer\GAL4en-e16E.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
EgfrKK100051
Name Synonyms
Secondary FlyBase IDs
    References (10)