Open Close
General Information
Symbol
Dmel\Hsc70-5KK100233
Species
D. melanogaster
Name
FlyBase ID
FBal0230627
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The expression of Hsc70-5KK100233 under the control of Scer\GAL4c564 leads to lethality.
Expression via Scer\GAL4tub.PU results in fragmented mitochondria and decreased mitochondrial membrane potential in peripodial cells of wing discs. Expression via Scer\GAL4tub.PU results in increased mitophagy in peripodial cells of wing discs. Expression via Scer\GAL4esg-NP5130 results in increased cell death of adult midgut progenitors.
Expression of Hsc70-5KK100233 under the control of Scer\GAL4GMR.PF does not cause any changes in external eye morphology upon fly ageing. Knockdown of Hsc70-5 through expression of Hsc70-5KK100233 in DA neurons using Scer\GAL4Ddc.PL or Scer\GAL4ple.PF, but not in sensory neurons, results in lethality during the larval or pupal stages. Knockdown of Hsc70-5 through expression of Hsc70-5KK100233 in motoneurons using Scer\GAL4RapGAP1-OK6, Scer\GAL4VGlut-OK371, or Scer\GAL4D42, results in either larval or pupal lethality. Expression of Hsc70-5KK100233 in the developing eye, under the control of Scer\GAL4GMR.PF does not cause degeneration in the external eyes of adult flies. Pan-neuronal expression of Hsc70-5KK100233 under the control of Scer\GAL4elav-C155, at 18[o]C, results in death before eclosion to adulthood. Larvae display no abnormal body-posture at rest or during locomotion. Suppression of early lethality in flies expressing Hsc70-5KK100233 under the control of Scer\GAL4elav-C155, through co-expression of Scer\GAL80ts.╬▒Tub84B, results in locomotion and body posture defects. These flies exhibit a 50% decrease in cellular ATP levels.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsc70-5KK100233
Name Synonyms
Secondary FlyBase IDs
    References (5)