Expression via Scer\GAL4tub.PU results in fragmented mitochondria and decreased mitochondrial membrane potential in peripodial cells of wing discs.
Expression via Scer\GAL4tub.PU results in increased mitophagy in peripodial cells of wing discs.
Expression via Scer\GAL4esg-NP5130 results in increased cell death of adult midgut progenitors.
Expression of Hsc70-5KK100233 under the control of Scer\GAL4GMR.PF does not cause any changes in external eye morphology upon fly ageing.
Knockdown of Hsc70-5 through expression of Hsc70-5KK100233 in DA neurons using Scer\GAL4Ddc.PL or Scer\GAL4ple.PF, but not in sensory neurons, results in lethality during the larval or pupal stages.
Knockdown of Hsc70-5 through expression of Hsc70-5KK100233 in motoneurons using Scer\GAL4RapGAP1-OK6, Scer\GAL4VGlut-OK371, or Scer\GAL4D42, results in either larval or pupal lethality.
Expression of Hsc70-5KK100233 in the developing eye, under the control of Scer\GAL4GMR.PF does not cause degeneration in the external eyes of adult flies.
Pan-neuronal expression of Hsc70-5KK100233 under the control of Scer\GAL4elav-C155, at 18[o]C, results in death before eclosion to adulthood. Larvae display no abnormal body-posture at rest or during locomotion.
Suppression of early lethality in flies expressing Hsc70-5KK100233 under the control of Scer\GAL4elav-C155, through co-expression of Scer\GAL80ts.αTub84B, results in locomotion and body posture defects. These flies exhibit a 50% decrease in cellular ATP levels.