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General Information
Symbol
Dmel\Akt1KK100495
Species
D. melanogaster
Name
FlyBase ID
FBal0230785
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Akt-RNAi, UAS-AKT1-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of Akt1KK100495 (driven by Scer\GAL4Dll-md23) in type II neuroblast lineage MARCM clones has no significant effect on the clone size or the number of progenitor cells it contains in third instar larvae.
Expression of Akt1KK100495 under the control of Scer\GAL4hh.PU results in decreased size of the posterior compartment in third instar larval wing discs.
Expression of Akt1KK100495 under the control of Scer\GAL4phm.PO does not significantly change the number of lipid droplets in the prothoracic gland cells of third instar larvae compared to controls.
Expression of Akt1KK100495 in the eye, under the control of Scer\GAL4GMR.PF, does not result in a visible phenotype.
Neuronal expression of Akt1KK100495 under the control of Scer\GAL4elav-C155 decreases sensitivity to ethanol sedation.
Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The overgrowth and increased number of progenitor cells characteristic for cnoR2;scrib1 type II neuroblast lineage MARCM clones is significantly suppressed by Scer\GAL4Dll-md23-driven expression of Akt1KK100495 in the mutant clones.
The AcnScer\UAS.cNa-induced rough eye phenotype is suppressed by co-expression of Akt1KK100495 (when both are expressed under the control of Scer\GAL4GMR.PF).
Expression of Akt1KK100495 suppresses the increase in circulating lamellocytes seen when ND75GD6309 is expressed under the control of Scer\GAL4Dot.PK.
Xenogenetic Interactions
Statement
Reference
Expression of Akt1KK100495 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Akt1KK100495
Name Synonyms
Secondary FlyBase IDs
    References (12)