Allele Dmel\Akt1^KK100495

General Information
Symbol	Dmel\Akt1^KK100495	Species	D. melanogaster
Name		FlyBase ID	FBal0230785
Feature type	allele	Associated gene	Dmel\Akt1

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Keleman et al., 2009.8.5) in vitro construct - RNAi (Keleman et al., 2009.8.5)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..403
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Keleman et al., 2009.8.5)
Carried in construct	P{KK100495} (Keleman et al., 2009.8.5, Eddison et al., 2011, Sinenko et al., 2011, Sinenko et al., 2010, Sinenko et al., 2011)
Associated Sequence Features	dsRNA-KK100495
Cytology
Phenotypic Data
Phenotypic Class
	chemical resistant, with Scer\GAL4^elav-C155 (Eddison et al., 2011)
Phenotype Manifest In

Detailed Description
	Statement Reference Neuronal expression of Akt1[KK100495] under the control of Scer\GAL4[elav-C155] decreases sensitivity to ethanol sedation. (Eddison et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Akt1^KK100495, Scer\GAL4^Hml.Δ is a suppressor \| partially of increased cell number \| third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa, Scer\GAL4^Hml.Δ (Sinenko et al., 2010)
Phenotype Manifest In
Suppressor of
Statement Reference Akt1^KK100495, Scer\GAL4^Dot.PK is a suppressor of lamellocyte \| larval stage phenotype of ND75^GD6309, Scer\GAL4^Dot.PK (Sinenko et al., 2011) Akt1^KK100495, Scer\GAL4^Hml.Δ is a suppressor \| partially of embryonic/larval hemocyte \| third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa, Scer\GAL4^Hml.Δ (Sinenko et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Expression of Akt1[KK100495] suppresses the increase in circulating lamellocytes seen when ND75[GD6309] is expressed under the control of Scer\GAL4[Dot.PK]. (Sinenko et al., 2011)
Xenogenetic Interactions
Statement Reference Expression of Akt1[KK100495] strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1[Scer\UAS.cSa] is expressed under the control of Scer\GAL4[Hml.Δ]. (Sinenko et al., 2010)
Complementation & Rescue Data
Comments
Stocks ( 1 )
VDRC	v103703 P{KK100495}VIE-260B
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Akt1^KK100495
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Sinenko et al., 2011, EMBO Rep. 13(1): 83--89 Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. [FBrf0217071] Sinenko et al., 2010, Blood 116(22): 4612--4620 Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. [FBrf0212361]
Supplementary material	Sinenko et al., 2011, EMBO Rep. 13(1): Supplementary information. [FBrf0219127]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]

Allele Dmel\Akt1KK100495

Allele Dmel\Akt1^KK100495