FlyBase Allele Report: Dmel\mask[KK100529]

General Information

Symbol

Dmel\mask^KK100529

Species

D. melanogaster

Name

FlyBase ID

FBal0230811

Feature type

allele

Associated gene

Dmel\mask

Associated Insertion(s)

Carried in Construct

P{KK100529}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100529}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100529

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Zhu et al., 2015)

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

abnormal starvation stress response | adult stage, with Scer\GAL4^Mef2.PU

(Havula et al., 2022)

abnormal starvation stress response | adult stage | nutrition conditional, with Scer\GAL4^NP0001

(Havula et al., 2022)

flightless, with Scer\GAL4^Mef2.PU

(Katzemich et al., 2015)

lethal - all die before end of P-stage, with Scer\GAL4^Mef2.PU

(Katzemich et al., 2015)

lethal - all die during pupal stage, with Scer\GAL4^how-24B

(Zhu et al., 2015)

majority die during larval stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

short lived | :calorie restriction conditional | nutrition conditional, with Scer\GAL4^NP0001

(Havula et al., 2022)

short lived | calorie restriction conditional, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

short lived | calorie restriction conditional, with Scer\GAL4^Mef2.PU

(Havula et al., 2022)

Phenotype Manifest In

indirect flight muscle cell | adult stage, with Scer\GAL4^Mef2.PU

(Katzemich et al., 2015)

myofibril | adult stage, with Scer\GAL4^Mef2.PU

(Katzemich et al., 2015)

sarcomere | adult stage, with Scer\GAL4^Mef2.PU

(Katzemich et al., 2015)

Detailed Description

Statement

Reference

Adults expressing mask^KK100529 under the control of Scer\GAL4^NP0001 show decreased survival to starvation when reared under high sugar diet.

(Havula et al., 2022)

Flies expressing mask^KK100529 under the control of Scer\GAL4^Mef2.PU die as late pupae at 29[o]C; at 25[o]C the flies manage to eclose but are flightless. The myofibrils in indirect flight muscles are thinner than in wild-type controls and the sarcomeres shorter. The myofibrils show a range of ultrastructural defects, in the severest cases all sarcomere structure is lost and Z disc structures form large clumps rather than orderly lines. These structural defects are visible also in the yet unused muscles from unhatched pupae.

(Katzemich et al., 2015)

Flies expressing mask^KK100529 under the control of Scer\GAL4^how-24B are pupal stage lethal.

(Zhu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

mask^KK100529/Scer\GAL4^how-24B is a suppressor of mitochondrion | third instar larval stage phenotype of Pink1^B9

(Zhu et al., 2015)

mask^KK100529/Scer\GAL4^how-24B is a suppressor of larval somatic muscle cell | third instar larval stage phenotype of Pink1^B9

(Zhu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The enlarged or aggregated mitochondria phenotype observed in the body wall muscles of Pink1^B9 hemizygous male third instar larvae is suppressed by expression of either mask^HMS01045 or mask^KK100529 under the control of Scer\GAL4^how-24B.

(Zhu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103411

P{KK100529}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mask^KK100529

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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