FlyBase Allele Report: Dmel\Jra[KK100582]

General Information

Symbol

Dmel\Jra^KK100582

Species

D. melanogaster

Name

FlyBase ID

FBal0230840

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

P{KK100582}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100582}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100582

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of movement | adult stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo

(Schmidt et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

RNAi knockdown of Jra, through expression of Jra^KK100582 in the posterior compartment of the wing disc, under the control of either Scer\GAL4^en.PU or Scer\GAL4^hh.PU, does not affect levels of cell death.

(Wong et al., 2014)

Adult flies expressing Jra^KK100582 under the simultaneous control of both Scer\GAL4^repo.PL and Scer\GAL4^repo are lethargic.

(Schmidt et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Jra^KK100582, Scer\GAL4^hh.PU, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Jra^KK100582, Scer\GAL4^en.PU, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

Jra^KK100582, Scer\GAL4^hh.PU, mad2^GD16427 has wing disc phenotype

(Wong et al., 2014)

Jra^KK100582, Scer\GAL4^en.PU, mad2^GD16427 has wing disc phenotype

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

There is a significant reduction in chromosome instability tolerance induced by mad2^GD16427 expression, when Jra^KK100582 is expressed in imaginal wing discs under the control of Scer\GAL4^en.PU or Scer\GAL4^hh.PU. There is also a concomitant significant increase in cell death in these double mutants.

(Wong et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107997

P{KK100582}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Jra^KK100582

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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