FB2025_01 , released February 20, 2025
Allele: Dmel\ItprKK100626
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General Information
Symbol
Dmel\ItprKK100626
Species
D. melanogaster
Name
FlyBase ID
FBal0230858
Feature type
allele
Associated gene
Dmel\Itpr
Associated Insertion(s)
Carried in Construct
P{KK100626}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK100626}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK100626
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q27.UAS.Tag:HA
      (Cho et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Itp-r83AKK100626 driven by Scer\GAL4phm.PO leads to developmental delay/arrest at the larval stage.

      (Yamanaka et al., 2015)

      Animals expressing Itp-r83AKK100626 under the control of Scer\GAL4fkh.PU show a reduction of autophagy in the salivary glands 14 hours after pupariation and salivary gland fragments persist in these animals 24 hours after puparium (no residual salivary gland material is present in wild-type animals at this stage).

      (Nelson et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      ItprKK100626, Scer\GAL4fkh.PU has salivary gland | pupal stage phenotype, non-suppressible by IP3K2Δ1

      (Nelson et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduction of autophagy which is seen in the salivary glands 14 hours after pupariation in animals expressing Itp-r83AKK100626 under the control of Scer\GAL4fkh.PU is still seen if the animals are also mutant for IP3K2Δ1.

      (Nelson et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Itp-r83AKK100626
      ItprKK100626
      Name Synonyms
      Secondary FlyBase IDs
        References (8)