FlyBase Allele Report: Dmel\Fs(2)Ket[KK100714]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Fs(2)Ket^KK100714

General Information

Symbol

Dmel\Fs(2)Ket^KK100714

Species

D. melanogaster

Name

FlyBase ID

FBal0230890

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

UAS-ketel RNAi

Key Links

Genomic Maps

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Khalil et al., 2022)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-PR^{25.UAS.Tag:FLAG}

(Boeynaems et al., 2016)

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^50.UAS.EGFP

(Lee et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior, with Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Fs(2)Ket^KK100714, Scer\GAL4^VGlut1-OK371 is a non-enhancer of decreased rate of adult locomotory behavior | progressive phenotype of Scer\GAL4^VGlut1-OK371, niki^GD7142

(Mann et al., 2023)

NOT Suppressor of

Statement

Reference

Fs(2)Ket^KK100714, Scer\GAL4^VGlut1-OK371 is a non-suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Scer\GAL4^VGlut1-OK371, niki^GD7142

(Mann et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v107622

P{KK100714}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Fs(2)Ket^KK100714

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections