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General Information
Symbol
Dmel\wmdKK100974
Species
D. melanogaster
Name
FlyBase ID
FBal0231018
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of wmdKK100974 under the control of either Scer\GAL4Mef2.PR or Scer\GAL4elav.PU (both with Dcr-2Scer\UAS.cUa) or driven by any of the following: Scer\GAL4c179, Scer\GAL4how-24B or Scer\GAL4da.PU (all without Dcr-2Scer\UAS.cUa) reduces adult viability to a varying degree (up to a point of complete lethality in some cases) at both 25[o]C and 29[o]C with more severe effects being observed at the higher temperature. Expression under Scer\GAL4tub.PU is completely lethal at both temperatures while expression under either Scer\GAL4G7 or Scer\GAL4RapGAP1-OK6 (with or without Dcr-2Scer\UAS.cUa) has practically no effect on viability.

Adult escapers expressing wmdKK100974 under the control of Scer\GAL4da.PU show wing defects.

Adult flies expressing wmdKK100974 (together with Dcr-2Scer\UAS.cUa to enhance RNAi efficiency) under the control of Scer\GAL4elav.PU are short lived and show age-progressive loss of flight ability compared to controls. This decline in flight performance is not observed when the Scer\GAL4Mef2.PR driver is used (without Dcr-2Scer\UAS.cUa).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

No decline in adult flight ability compared to controls is observed when wmdKK100974 and Gem3ΔN.Scer\UAS are co-expressed under the Scer\GAL4Mef2.PR driver.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
wmdKK100974
Name Synonyms
Secondary FlyBase IDs
    References (2)