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General Information
Symbol
Dmel\gwKK101472
Species
D. melanogaster
Name
FlyBase ID
FBal0231290
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of gwKK101472 under the control of Scer\GAL4c564 has no obvious affect on the inflammatory response to Gram-positive bacterial infection or under basal conditions, as compared to controls.

Flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa to increase RNAi efficiency) are arrhythmic for locomotor activity under constant darkness conditions.

Circadian behaviour under 12 hour light/12 hour dark conditions is altered in flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa) The morning peak of activity is severely blunted, although a robust evening peak is still present. The phase of the evening peak of activity is advanced compared to control flies.

Only 25% of flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa) and in the presence of Scer\GAL80Pdf.PS (to further restrict Scer\GAL4 expression) are rhythmic for locomotor activity under constant darkness conditions. Under 12 hour light/12 hour dark conditions morning anticipation is decreased and the phase of the evening peak of activity is advanced compared to controls.

Flies expressing gwKK101472 under the control of Scer\GAL4P2.4.Pdf show normal circadian locomotor behaviour under both 12 hour light/12 hour dark and constant darkness conditions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of PdfScer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 rescues rhythmic locomotor behaviour under constant darkness conditions in 67.5% of flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa to increase RNAi efficiency). The locomotor activity defects seen under 12 hour light/12 hour dark conditions in flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa) are not suppressed by co-expression of PdfScer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1.

Co-expression of PdfScer\UAS.SCR.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 does not rescue rhythmic locomotor behaviour under constant darkness conditions in flies expressing gwKK101472 under the control of Scer\GAL4tim.PE (in the presence of Dcr-2Scer\UAS.cDa).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
gwKK101472
Name Synonyms
Secondary FlyBase IDs
    References (5)