Open Close
General Information
Symbol
Dmel\hpoKK101704
Species
D. melanogaster
Name
FlyBase ID
FBal0231432
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-hpo RNAi, hpo RNAi, UAS-hpo-RNAi, UAS-hpoRNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing hpoKK101704 under the control of Scer\GAL4ptc.PU results in a reduced area between L3 and L4 in the wing.

Expression under the control of Scer\GAL4GMR.PU leads to an enlarged eye.

Expressing hpoKK101704 under the control of Scer\GAL4ptc-559.1 results in a significant expansion of the anterior-posterior compartment boundary of the wing disc, while expression under the control of Scer\GAL4hh-Gal4 causes an expansion of the wing disc posterior compartment in third instar larvae.

The expression of hpoKK101704 under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) leads to a significant increase in wing size, as compared to controls.

Expressing hpoKK101704 under the control of Scer\GAL4insc-Mz1407 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in a significant volume increase of the central nervous system at third instar larval stage.

Somatic clones of type I lineages expressing hpoKK101704 under the control of Scer\GAL4Tub.PU show a significant increase in volume in the ventral nerve cord compared to controls.

Type I neuroblasts in somatic clones expressing hpoKK101704 under the control of Scer\GAL4NP1316 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) maintain cell polarity typical of wild-type controls.

Expression of hpoKK101704 under the control of Scer\GAL4esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in a significant increase in the number of mitotic cells in the midgut, as compared to controls.

Expression of hpoKK101704 (co-expressed with Dcr-2Scer\UAS.cDa) under the control of Scer\GAL4repo.PU substantially increases glial cell numbers in the third instar larval eye disc and brain.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The double co-expression of hpoKK101704 and SmoxNIG.2262R under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) suppresses the wing defects induced by the single expression conditions.

Co-expression of bunGD1392 suppresses the increased number of mitotic cells seen in the midguts of flies expressing hpoKK101704 under the control of Scer\GAL4esg-NP5130.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
hpoKK101704
Name Synonyms
Secondary FlyBase IDs
    References (18)