FB2025_05 , released December 11, 2025
Allele: Dmel\PakKK101874
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General Information
Symbol
Dmel\PakKK101874
Species
D. melanogaster
Name
FlyBase ID
FBal0231538
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
P{KK101874}
Also Known As
Pak RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK101874}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK101874
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PakKK101874 under the control of Scer\GAL4ato.3.6 results in a decrease in the number of medulla axons compared to wild type.

      (Langen et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      PakKK101874, Scer\GAL4ato.3.6 has medulla phenotype, non-suppressible by NECN.UAS, Scer\GAL4ato.3.6

      (Langen et al., 2013)
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      PakKK101874, Scer\GAL4ato.3.6 is a suppressor of medulla phenotype of NECN.UAS, Scer\GAL4ato.3.6

      (Langen et al., 2013)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The strong reduction in wing area seen in flies co-expressing all of hpoScer\UAS.cUa, RtGEFScer\UAS.T:Ivir\HA1 and GitScer\UAS.T:Hsap\MYC under the control of Scer\GAL4nub.PU is unaffected if they are also carrying either PakKK101874.

      (Dent et al., 2015)

      The number of medulla axons in animals co-expressing both PakKK101874 and NECN.Scer\UAS under the control of Scer\GAL4ato.3.6 is indistinguishable from seen in animals expressing PakKK101874 alone under the control of Scer\GAL4ato.3.6.

      (Langen et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pak1KK101874
      (Bondar et al., 2018)
      Pak1RNAi-1
      (Bondar et al., 2018)
      PakKK101874
      (Singh et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)