FlyBase Allele Report: Dmel\ZnT63C[KK102261]

General Information

Symbol

Dmel\ZnT63C^KK102261

Species

D. melanogaster

Name

FlyBase ID

FBal0231694

Feature type

allele

Associated gene

Dmel\ZnT63C

Associated Insertion(s)

Carried in Construct

P{KK102261}

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Keleman et al., 2009.8.5)

in vitro construct - regulatory fusion

(Keleman et al., 2009.8.5)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{KK102261}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ZnT63C

Associated Sequence Features

dsRNA-KK102261

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

DOES NOT ameliorate xanthinuria

modeled by ry^HMS02827

(Yin et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

chemical sensitive, with Scer\GAL4^NP1093

(Yin et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing ZnT63C^KK102261 under the control of Scer\GAL4^fkh.PH does not significantly affect the clearing of salivary gland tissue in pupae, as compared to controls.

(Velentzas et al., 2018)

The expression of ZnT63C^KK102261 under the control of Scer\GAL4^{CG10962-NP1093} leads to a significant increase in the eclosion rate of animals reared in food supplemented with zinc at 5mM and above (but not at 2mM and below), but not of animals reared in normal food or food supplemented with a zinc chelator, as compared to wild-type controls.

(Yin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ZnT63C^KK102261/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is an enhancer of eye color defective phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/ZnT63C^KK102261 is a suppressor | partially of short lived phenotype of ry^GD8894

(Chi et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is a suppressor | partially of eye color defective phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP1093/ZnT63C^KK102261 is a non-suppressor of chemical sensitive phenotype of Scer\GAL4^NP1093, Zip71B^GD2461

(Yin et al., 2017)

ZnT63C^KK102261/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

Other

Statement

Reference

Scer\GAL4^GMR.long, Zip42C.1^UAS.EGFP, ZnT63C^KK102261 has visible | adult stage phenotype

(Dechen et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

ZnT63C^KK102261/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/ZnT63C^KK102261 is a suppressor of Malpighian tubule phenotype of Scer\GAL4^da.PU, ry^GD8894

(Chi et al., 2015)

ZnT63C^KK102261/Scer\GAL4^GMR.long is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP1093/ZnT63C^KK102261 is a non-suppressor of embryonic/larval Malpighian tubule | third instar larval stage phenotype of Scer\GAL4^NP1093, ry^HMS02827

(Yin et al., 2017)

ZnT63C^KK102261/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

Other

Statement

Reference

Scer\GAL4^GMR.long, Zip42C.1^UAS.EGFP, ZnT63C^KK102261 has eye phenotype

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of ZnT63C^KK102261 does not suppress the decreased eclosion rate exhibited by animals expressing Zip71B^GD2461 under the control of Scer\GAL4^{CG10962-NP1093} reared in zinc-supplemented food; under normal diet conditions, the co-expression of Zip71B^GD2461 and ZnT63C^KK102261 under the control of Scer\GAL4^{CG10962-NP1093} has no significant effect on the eclosion rate, as compared to animals only expressing either Zip71B^GD2461 or ZnT63C^KK102261 under the control of Scer\GAL4^{CG10962-NP1093}.

The formation of Malpighian tubule stones in third instar larvae induced by the expression of ry^HMS02827 under the control of Scer\GAL4^{CG10962-NP1093} is not suppressed by the co-expression of ZnT63C^KK102261.

(Yin et al., 2017)

Expression of ZnT63C^KK102261 suppresses the malpighian tubule concretions seen when ry^GD8894 is expressed under the control of Scer\GAL4^da.PU. The reduced lifespan is also partially suppressed.

(Chi et al., 2015)

The adult eye phenotype seen upon expression of ZnT86D^Scer\UAS.cDa under the control of Scer\GAL4^GMR.long can be partially modified by co-expression of ZnT63C^KK102261 RNAi: the morphological defects are unchanged but the pigmentation loss is strongly worsened.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long are mildly ameliorated by co-expression of ZnT63C^KK102261 RNAi.

The morphological defects in the adult eye seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long are severely exacerbated by co-expression of ZnT63C^KK102261 RNAi; the effect on pigmentation loss is not assessable as the eyes are almost completely lost.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105145

P{KK102261}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ZnT63C^KK102261

dZnT63C^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

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