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General Information
Symbol
Dmel\ApplKK102543
Species
D. melanogaster
Name
FlyBase ID
FBal0231851
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
APPL-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ApplKK102543 under the control of Scer\GAL4VT064246 (using tub-Gal80[ts] to limit the expression to adulthood) results in significantly reduced middle- as well as long-term memory compared to controls (tested in an aversive olfactory memory assay 2hr and 24hr post-training, respectively), but their learning performance is not affected.

After 48 hours of RU feeding, Scer\GAL4Mef2.247.Switch driven expression of ApplKK102543 results in flies that exhibit a STM deficit. This deficit is only observed when the flies are fed with RU to induce RNAi expression.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
ApplKK102543
Name Synonyms
Secondary FlyBase IDs
    References (3)