FlyBase Allele Report: Dmel\Kdm5[KK102745]

General Information

Symbol

Dmel\Kdm5^KK102745

Species

D. melanogaster

Name

FlyBase ID

FBal0231981

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{KK102745}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102745}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102745

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Pinzón et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

visible | adult stage | female, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

posterior crossvein, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing blade | female, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of lid^KK102745 under the control of Scer\GAL4^nub.PK results in incomplete posterior crossvein phenotype in the adults, although the penetrance is rather low (around 20%) and in crinkled and blistered wing phenotype in adult females.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Kdm5^KK102745, Scer\GAL4^nub.PK has visible | adult stage phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Kdm5^KK102745, Scer\GAL4^nub.PK has visible | female | adult stage phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Kdm5^KK102745, Scer\GAL4^nub.PK has posterior crossvein phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Kdm5^KK102745, Scer\GAL4^nub.PK has wing blade | female phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing defects induced by expression of lid^KK102745 under the control of Scer\GAL4^nub.PK is strongly decreased by co-expression of htt^GD14943.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103830

P{KK102745}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Kdm5^KK102745

lid^KK102745

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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