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General Information
Symbol
Dmel\MED27KK102849
Species
D. melanogaster
Name
FlyBase ID
FBal0232050
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of MED27KK102849 under the control of Scer\GAL4bam.T:Hsim\VP16 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in partial meiotic arrest in spermatocytes.

Expression via Scer\GAL4wor.PA and Scer\GAL80ase.PN prolongs the lifetime and prevents shrinkage of pupal neuroblasts (NBs) without having any obvious effects on larval NBs. These longer lived NBs continue dividing for a longer time and generate significantly more neuronal progeny than wild type.

Cultured pupal neuroblasts (NBs) from flies expressing MED27KK102849 under the control of Scer\GAL4wor.PA and Scer\GAL80ase.PN do not reduce their net size (as wild type pupal NBs do) and are indistinguishable from larval NBs.

Expression via Scer\GAL4ey-OK107 prevents proper differentiation of alpha/beta neurons in mushroom bodies, resulting in a smaller volume.

Expression via Scer\GAL4insc-Mz1407 reduces the difference (increase) in oxygen consumption rates seen in wild type larval vs pupal brains. NADH levels are decreased, but overall energy/ATP levels are unchanged. Lactate levels are reduced in larvae and increased in pupae, effectively reducing the difference between the two stages, whereas lactate levels strongly decrease from larval to pupal stages in wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
MED27KK102849
Name Synonyms
Secondary FlyBase IDs
    References (3)