FlyBase Allele Report: Dmel\Myc[KK103869]

General Information

Symbol

Dmel\Myc^KK103869

Species

D. melanogaster

Name

FlyBase ID

FBal0232572

Feature type

allele

Associated gene

Dmel\Myc

Associated Insertion(s)

Carried in Construct

P{KK103869}

Also Known As

myc-RNAi, Myc RNAi, UAS-dMycRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK103869}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK103869

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain cancer

modeled by brat^KK113206

(Rebelo and Homem, 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal dorsal adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

abdominal lateral adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

abdominal ventral adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^repo.PU

(Reddy and Irvine, 2011)

intermediate neuronal progenitor | larval stage, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

larval brain | third instar larval stage, with Scer\GAL4^repo.PU

(Reddy and Irvine, 2011)

wing, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

wing, with Scer\GAL4^Bx-MS1096-KE

(Li et al., 2013)

wing | posterior, with Scer\GAL4^en.PU

(Li et al., 2013)

wing | posterior, with Scer\GAL4^en-e16E

(Djiane et al., 2013)

Detailed Description

Statement

Reference

The co-expression of Myc^KK103869 moderately suppresses the adult lethality of individuals expressing brat^GD7073 under the combined control of Scer\GAL4^wor.PA, Scer\GAL80^ase.PN.

(Reichardt et al., 2018)

Larval brains expressing Myc^KK103869 under the control of Scer\GAL4^insc-Mz1407 exhibit a significant decrease in the numbers of immature and mature secondary neuroblasts per type II neuroblast lineage, as compared to controls.

(Wu et al., 2017)

The expression of Myc^KK103869 under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to significantly decreased numbers of abdominal lateral, dorsal and ventral adult muscle precursor cells in third instar larvae, as compared to controls.

(Aradhya et al., 2015)

Expression of Myc^KK103869 under the control of Scer\GAL4^Bx-MS1096 results in male flies with weak wing size and patterning defects.

Expression of Myc^KK103869 under the control of Scer\GAL4^Bx-MS1096 results in female flies with weak wing size and patterning defects.

(Schertel et al., 2015)

Scer\GAL4^Ilp2.PR-mediated expression results in a significant reduction in the body weight of emerging adults compared to controls.

(Hasygar and Hietakangas, 2014)

Scer\GAL4^en-e16E-mediated expression results in a strong reduction in size of the posterior compartment of the adult wing.

(Djiane et al., 2013)

Scer\GAL4^Bx-MS1096-KE-mediated expression of dm^KK103869 causes the adult wing to curve upwards (indicative of decreased cell size in the dorsal layer).

Scer\GAL4^en.PU-mediated expression of dm^KK103869 significantly decreases the area of the posterior compartment of the wing, as well as the ratio between the posterior and anterior areas, owing to reduced cell size.

Scer\GAL4^en.PU-mediated expression of dm^KK103869 does not generate a wing vein phenotype.

(Li et al., 2013)

Expression of dm^KK103869 (co-expressed with Dcr-2^Scer\UAS.cDa) under the control of Scer\GAL4^repo.PU substantially increases glial cell numbers in the third instar larval eye disc and brain.

(Reddy and Irvine, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Myc^KK103869, Scer\GAL4^insc-Mz1407 has decreased cell number | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Myc^KK103869, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Suppressor of

Statement

Reference

Myc^KK103869, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Scer\GAL80^ase.PN, Myc^KK103869, Scer\GAL4^wor.PA is a suppressor of partially lethal - majority die phenotype of Scer\GAL4^wor.PA, Scer\GAL80^ase.PN, brat^GD7073

(Reichardt et al., 2018)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^insc-Mz1407, mir-ban^D.UAS.EGFP

(Wu et al., 2017)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^insc-Mz1407, numb^HMS01459

(Wu et al., 2017)

Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.UAS.Tag:V5}

(Reddy and Irvine, 2011)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^repo.PU, mir-ban^GS

(Reddy and Irvine, 2011)

NOT Suppressor of

Statement

Reference

Myc^KK103869/Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of abnormal neuroanatomy | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Other

Statement

Reference

InR^K414P.UAS, Myc^KK103869, Scer\GAL4^{E(spl)m6-BFM.PF} has decreased cell number | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has decreased cell number | third instar larval stage phenotype

(Aradhya et al., 2015)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Myc^KK103869, Scer\GAL4^insc-Mz1407 has intermediate neuronal progenitor | larval stage phenotype, non-suppressible by numb^HMS01459, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Suppressor of

Statement

Reference

Myc^KK103869, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of intermediate neuronal progenitor | larval stage phenotype of Scer\GAL4^insc-Mz1407, mir-ban^D.UAS.EGFP

(Wu et al., 2017)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of nucleolus | larval stage phenotype of Scer\GAL4^insc-Mz1407, mir-ban^D.UAS.EGFP

(Wu et al., 2017)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of intermediate neuronal progenitor | larval stage phenotype of Scer\GAL4^insc-Mz1407, numb^HMS01459

(Wu et al., 2017)

Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of nucleolus | larval stage phenotype of Scer\GAL4^insc-Mz1407, numb^HMS01459

(Wu et al., 2017)

Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of type II neuroblast | increased number phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Myc^KK103869, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, puf^EP3472

(Li et al., 2013)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of eye disc | third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.UAS.Tag:V5}

(Reddy and Irvine, 2011)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of larval glial cell | third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.UAS.Tag:V5}

(Reddy and Irvine, 2011)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of eye disc | third instar larval stage phenotype of Scer\GAL4^repo.PU, mir-ban^GS

(Reddy and Irvine, 2011)

Myc^KK103869, Scer\GAL4^repo.PU is a suppressor of larval glial cell | third instar larval stage phenotype of Scer\GAL4^repo.PU, mir-ban^GS

(Reddy and Irvine, 2011)

NOT Suppressor of

Statement

Reference

Myc^KK103869/Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of neuroblast | ectopic | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Myc^KK103869/Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of adult optic lobe | somatic clone | larval stage phenotype of nerfin-1¹⁵⁹

(Xu et al., 2017)

Other

Statement

Reference

InR^K414P.UAS, Myc^KK103869, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal lateral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

InR^K414P.UAS, Myc^KK103869, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal dorsal adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

InR^K414P.UAS, Myc^KK103869, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal ventral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal lateral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal dorsal adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal ventral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of numb^HMS01459 fails to suppress the decreased numbers of immature and mature secondary neuroblasts seen in larval brains expressing Myc^KK103869 under the control of Scer\GAL4^insc-Mz1407.

Co-expression of Myc^KK103869 suppresses the increased nucleolar size seen in secondary neuroblasts in larval brains expressing ban^{D.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^insc-Mz1407.

Co-expression of Myc^KK103869 suppresses the increased nucleolar size seen in secondary neuroblasts of larval brains expressing numb^HMS01459 under the control of Scer\GAL4^insc-Mz1407.

(Wu et al., 2017)

Clonal expression of Myc^KK103869 under the control of Scer\GAL4^tub.PU fails to suppress the formation of ectopic neuroblasts in larval optic lobe nerfin-1¹⁵⁹/nerfin-1¹⁵⁹ mutant clones.

(Xu et al., 2017)

Co-expression of Myc^KK103869 suppresses the increased number of abdominal lateral and dorsal adult muscle precursor cells present in third instar larvae expressing InR^{R418P.Scer\UAS} under the control of Scer\GAL4^{E(spl)m6-BFM.PF}, even leading to their decrease in numbers, as compared to controls; co-expressing Myc^KK103869 and InR^{R418P.Scer\UAS} also results in decreased numbers of abdominal ventral adult muscle precursor cells in third instar larvae, as compared to controls.

The co-expression of Myc^KK103869 and N^ICN.Scer\UAS under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to significantly decreased numbers of abdominal lateral, dorsal and ventral adult muscle precursor cells in third instar larvae, as compared to controls.

(Aradhya et al., 2015)

Simultaneous co-expression of both Pink1^{dsRNA.Scer\UAS} and dm^KK103869 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

(Lee et al., 2013)

Expression of dm^KK103869 (co-expressed with Dcr-2^Scer\UAS.cDa) suppresses the increase in glial cell number seen in larval eye discs expressing yki^{S168A.Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^repo.PU.

Expression of dm^KK103869 (co-expressed with Dcr-2^Scer\UAS.cDa) suppresses the increase in glial cell number seen in larval eye discs expressing ban^GS under the control of Scer\GAL4^repo.PU.

(Reddy and Irvine, 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106066

P{KK103869}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Myc^KK103869

dm^KK103869

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections