FlyBase Allele Report: Dmel\Dronc[KK104278]

General Information

Symbol

Dmel\Dronc^KK104278

Species

D. melanogaster

Name

FlyBase ID

FBal0232868

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{KK104278}

Also Known As

UAS-dsRNA^dronc

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK104278}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK104278

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

(Zheng et al., 2025)

lethal, with Scer\GAL4^Tub.PU

(Dembeck et al., 2015)

lethal, with Scer\GAL4^Ubi.PU

(Dembeck et al., 2015)

Phenotype Manifest In

dendrite | P-stage, with Scer\GAL4^ppk.PU

(Zheng et al., 2025)

larval multidendritic class IV neuron | P-stage, with Scer\GAL4^ppk.PU

(Zheng et al., 2025)

Detailed Description

Statement

Reference

Expression of Dronc^KK104278 RNAi under the control of Scer\GAL4^pnr-MD237 does not change the level of pigmentation on the abdominal tergite 5 or 6 in adult females compared to controls.

(Dembeck et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dronc^KK104278/Scer\GAL4⁴⁷⁷ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

Strica^GD12308, Scer\GAL4^en.PU, Dronc^KK104278 is a suppressor of increased cell death | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Scer\GAL4^en.PU/Dronc^KK104278 is a suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Strica^GD12308, Scer\GAL4^en.PU, Dronc^KK104278 is a suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Dronc^KK104278, Scer\GAL4^dpp.blk1 is a suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^en.PU/Dronc^KK104278 is a non-suppressor of increased cell death | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dronc^KK104278/Scer\GAL4⁴⁷⁷ is a suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

Dronc^KK104278/Scer\GAL4⁴⁷⁷ is a suppressor of dendrite | third instar larval stage phenotype of nanos⁵³/nanos¹⁸

(Bhogal et al., 2016)

Dronc^KK104278, Scer\GAL4^dpp.blk1 is a suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The dendritic arborization defects observed in class IV dendritic arborizing neurons of nos¹⁸/nos⁵³ third instar larvae is suppresed by or by expression of Dronc^KK104278 under the control of Scer\GAL4⁴⁷⁷ in the mutant background.

(Bhogal et al., 2016)

Scer\GAL4^en.PU-mediated expression of both Dronc^KK104278 and Strica^GD12308 together, but neither alone, prevents competitive cell death at RpS3^Plac92/+ boundaries with +/+ cells.

Scer\GAL4^en.PU-mediated expression of both Dronc^KK104278 and Strica^GD12308 together or Dronc^KK104278 alone, but not Strica^GD12308 alone allows survival of RpS3^Plac92 homozygous cell clones.

(Kale et al., 2015)

Xenogenetic Interactions

Statement

Reference

The adult wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1 are almost complement suppressed by co-expression of Nc^KK104278.

(Marchal et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100424

P{KK104278}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dronc^KK104278

Nc^KK104278

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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