FB2025_01 , released February 20, 2025
Allele: Dmel\Cyp303a1KK105532
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General Information
Symbol
Dmel\Cyp303a1KK105532
Species
D. melanogaster
Name
FlyBase ID
FBal0233623
Feature type
allele
Associated gene
Dmel\Cyp303a1
Associated Insertion(s)
Carried in Construct
P{KK105532}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK105532}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK105532
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cyp303a1KK105532 under the constitutive control of Scer\GAL4αTub84B.PL (alone or in combination with Dicer-2 which enhances the phenotype) leads to partial embryonic lethality when compared to controls. Among the survivors, some fail to escape from the puparium and die, whereas others are able to escape from the puparium, but unable to spread the wings and die within three hours after adult emergence when compared to controls.

      Expression of Cyp303a1KK105532 under the control of Scer\GAL4Bx-MS1096 but not Scer\GAL4c601, Scer\GAL4Cg.PA, Scer\GAL4Hml.Δ, Scer\GAL4ppl.PP, Scer\GAL4btl.PS, Scer\GAL4Mef2.PR, Scer\GAL460IIA, Scer\GAL4phm.PO, Scer\GAL4Aug21 or Scer\GAL4Akh.PL leads to defects in wing extension when compared to controls.

      Temporally restricted expression of Cyp303a1KK105532 under the control of Scer\GAL4αTub84B.PL (in combination with tub-Gal80[ts]) leads to animals deficient in eclosion or wing expansion when the expression is restricted to whole pupal stage or different intervals during pupal development (starting at 48 h, 96 h, 144 h after puparium formation (APF) until reaching adulthood) while it leads to viable animals with no visible phenotypes when the expression is restricted to whole embryonic stages, whole larval stages or the pupal interval -192 APF to adulthood- when compared to controls.

      (Wu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cyp303a1KK105532
      Name Synonyms
      Secondary FlyBase IDs
        References (2)