FlyBase Allele Report: Dmel\rept[KK105732]

General Information

Symbol

Dmel\rept^KK105732

Species

D. melanogaster

Name

FlyBase ID

FBal0233744

Feature type

allele

Associated gene

Dmel\rept

Associated Insertion(s)

Carried in Construct

P{KK105732}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK105732}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK105732

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | male, with Scer\GAL4^VP16.bam

(Zur Lage et al., 2018)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

lethal, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

lethal, with Scer\GAL4^sca.PU

(Zur Lage et al., 2019, Zur Lage et al., 2018)

male sterile, with Scer\GAL4^VP16.bam

(Zur Lage et al., 2019, Zur Lage et al., 2018)

partially lethal - majority die, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

spermatid, with Scer\GAL4^VP16.bam

(Zur Lage et al., 2018)

spermatid axoneme, with Scer\GAL4^VP16.bam

(Zur Lage et al., 2018)

spermatozoon, with Scer\GAL4^VP16.bam

(Zur Lage et al., 2019)

wing, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expressing rept^KK105732 under the control of Scer\GAL4^VP16.bam results in immotile sperm.

(Zur Lage et al., 2019)

Testes in individuals expressing rept^KK105732 under the control of Scer\GAL4^VP16.bam lack motile sperm despite sperm bundles being largely normal, as compared to controls.

(Zur Lage et al., 2018)

Expression of rept^KK105732 under the control of any of the following: Scer\GAL4^Act5C.PI, Scer\GAL4^ey.PH or Scer\GAL4^en.PU is completely lethal and largely so when driven by Scer\GAL4^nub.PK - only few escapers eclose and those have no wings. Expression controlled by Scer\GAL4^GMR.PF has no overt adult phenotype.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103483

P{KK105732}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

rept^KK105732

reptin^KK105732

(Bailetti et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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