FlyBase Allele Report: Dmel\ena[KK107752]

General Information

Symbol

Dmel\ena^KK107752

Species

D. melanogaster

Name

FlyBase ID

FBal0235144

Feature type

allele

Associated gene

Dmel\ena

Associated Insertion(s)

Carried in Construct

P{KK107752}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107752}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107752

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal-ventral compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^sd-SG29.1

(Becam et al., 2011)

indirect flight muscle cell | P-stage, with Scer\GAL4^kirre.PU

(Segal et al., 2016)

myotube | P-stage, with Scer\GAL4^kirre.PU

(Segal et al., 2016)

Detailed Description

Statement

Reference

Expressing ena^KK107752 under the control of Scer\GAL4^dome.PU does not induce melanotic masses in third instar larvae.

(Bernardoni et al., 2019)

Expression of ena^KK107752 under the control of Scer\GAL4^kirre.PU (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in defective splitting of muscle fibers and fusion defects in myotubes, with a reduction in the number of small nuclei originating from fusing myoblasts.

(Segal et al., 2016)

Late third instar mutant wing discs expressing ena^KK107752 under the control of Scer\GAL4^sd-SG29.1 exhibit increased boundary cell proliferation, compromising the dorsal-ventral affinity boundary. The anterior-posterior boundary is unaffected.

(Becam et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ena^KK107752/Scer\GAL4^elav.PLu is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Abl²/Abl¹

(Sun et al., 2024)

ena^KK107752/Scer\GAL4^elav.PLu is a suppressor | partially of abnormal cell size | P-stage phenotype of Abl²/Abl¹