FlyBase Allele Report: Dmel\Ufd1[KK108134]

General Information

Symbol

Dmel\Ufd1^KK108134

Species

D. melanogaster

Name

FlyBase ID

FBal0235373

Feature type

allele

Associated gene

Dmel\Ufd1

Associated Insertion(s)

Carried in Construct

P{KK108134}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108134}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108134

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Byrne et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegenerative disease

is exacerbated by TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nSyb.PS

(Byrne et al., 2017)

abnormal locomotor behavior | larval stage, with Scer\GAL4^nSyb.PS

(Byrne et al., 2017)

lethal - all die before end of P-stage, with Scer\GAL4^da.G32

(Byrne et al., 2017)

some die during larval stage, with Scer\GAL4^da.G32

(Byrne et al., 2017)

viable, with Scer\GAL4^nSyb.PS

(Byrne et al., 2017)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^nSyb.PS

(Byrne et al., 2017)

microtubule | larval stage, with Scer\GAL4^nSyb.PS

(Byrne et al., 2017)

Detailed Description

Statement

Reference

The expression of Ufd1-like^KK108134 under the control of Scer\GAL4^da.G32 induces significant locomotor defects in both larvae (lower distances traveled) and adults (progressive decrease in climbing behavior in negative geotaxis assays). Larval NMJs show microtubules defects (frequently lacking Futsch staining) but apparently normal branch sizes, as compared to controls. Motor neuron axons do not show any obvious microtubule or ER defects.

(Byrne et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nSyb.PS, Ufd1^KK108134 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Scer\GAL4^nSyb.PS/TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS, Ufd1^KK108134 has short lived phenotype, enhanceable by Scer\GAL4^nSyb.PS/TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS, Ufd1^KK108134 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Scer\GAL4^nSyb.PS/TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^nSyb.PS, Ufd1^KK108134 has abnormal locomotor behavior | larval stage phenotype, non-enhanceable by Scer\GAL4^nSyb.PS/TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^nSyb.PS, Ufd1^KK108134 has abnormal locomotor behavior | larval stage phenotype, non-suppressible by Scer\GAL4^nSyb.PS/TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^nSyb.PS, TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

NOT Enhancer of

Statement

Reference

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-enhancer of short lived phenotype of Scer\GAL4^nSyb.PS, TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^nSyb.PS, TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-enhancer of short lived phenotype of Scer\GAL4^nSyb.PS, TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-suppressor of short lived phenotype of Scer\GAL4^nSyb.PS, TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^nSyb.PS, TBPH^{UAS.10x.Venus}

(Byrne et al., 2017)

Scer\GAL4^nSyb.PS/Ufd1^KK108134 is a non-suppressor of short lived phenotype of Scer\GAL4^nSyb.PS, TBPH^RNAi.UAS.cDa

(Byrne et al., 2017)

Other

Statement

Reference

Scer\GAL4^GMR.PF, TER94^A229E.UAS, Ufd1^KK108134 has lethal phenotype

(Liang et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Ufd1-like^KK108134 with TER94^{A229E.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in lethality.

Expression of Ufd1-like^KK108134 does not reverse the suppressive effect of Der-1^Scer\UAS.cLa on the rough eye and photoreceptor degeneration phenotypes seen when TER94^{R188Q.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Liang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104713

P{KK108134}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ufd1-like^KK108134

Ufd1^KK108134

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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