Allele Dmel\Wbp2^KK108304

General Information
Symbol	Dmel\Wbp2^KK108304	Species	D. melanogaster
Name		FlyBase ID	FBal0235487
Feature type	allele	Associated gene	Dmel\Wbp2

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Keleman et al., 2009.8.5) in vitro construct - RNAi (Keleman et al., 2009.8.5)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..273
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Keleman et al., 2009.8.5)
Carried in construct	P{KK108304} (Zhang et al., 2011, Keleman et al., 2009.8.5)
Associated Sequence Features	dsRNA-KK108304
Cytology
Phenotypic Data
Phenotypic Class
	size defective, with Scer\GAL4^hh.PU (Zhang et al., 2011)
Phenotype Manifest In
	wing margin, with Scer\GAL4^hh.PU (Zhang et al., 2011)
Detailed Description
	Statement Reference Scer\GAL4[hh.PU]-mediated expression of Wbp2[KK108304] produces wings with scalloped edges that are reduced in size. (Zhang et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a suppressor of lethal \| somatic clone phenotype of wts^x1 (Zhang et al., 2011)
NOT Suppressor of
Statement Reference Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a non-suppressor of size defective \| somatic clone phenotype of Tsc1^Q87X (Zhang et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a suppressor of eye disc \| somatic clone phenotype of wts^x1 (Zhang et al., 2011) Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a suppressor of morphogenetic furrow \| somatic clone phenotype of wts^x1 (Zhang et al., 2011) Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a suppressor of ommatidial precursor cluster \| somatic clone phenotype of wts^x1 (Zhang et al., 2011)
NOT Suppressor of
Statement Reference Wbp2^KK108304/Scer\GAL4^αTub84B.PL is a non-suppressor of eye \| somatic clone phenotype of Tsc1^Q87X (Zhang et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference When Wbp2[KK108304] is expressed in wts[x1]-deficient tissues using eyFlp/MARCM, a significant increase in survival is observed with the majority of flies now reaching late pupal stages and forming pharate adults, with a small number emerging as fully developed adults. When Wbp2[KK108304] is expressed in wts[x1]-deficient tissues using eyFlp/MARCM, eye disc size is reduced, the amount of wts[x1] tissue relative to wild type tissue is decreased, and the differentiation of the developing eye is almost completely restored. Eyes remain overgrown when Wbp2[KK108304] is expressed in Tsc1[Q87X]-deficient eyes using eyFlp/MARCM. (Zhang et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
VDRC	v108260 P{KK108304}VIE-260B
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11009^KK108304 Wbp2^KK108304
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Zhang et al., 2011, Cell Death Differ. 18(8): 1346--1355 Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. [FBrf0214266]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]

Allele Dmel\Wbp2KK108304

Allele Dmel\Wbp2^KK108304