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General Information
Symbol
Dmel\5-HT1AKK108407
Species
D. melanogaster
Name
FlyBase ID
FBal0235551
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Temporal expression of 5-HT1AKK108407 under the control of Scer\GAL4c739 during adulthood (by using Gal80[ts]) decreases olfactory medium term memory (1h) when the experiment is carried out in crowded conditions (groups of 32 flies - socially facilitated memory).

Pan-neuronal expression of 5-HT1AKK108407 in adult flies (using 31[o]C heat-induced Scer\GAL4nSyb.PS in combination with Scer\GAL80ts.αTub84B) does not significantly affect wall following behavior (posited measure of anxiety) in an arena, but does significantly decrease walking speed compared to non-induced (18[o]C) controls.

Starved adult male flies expressing 5-HT1AKK108407 under the control of Scer\GAL4Ilp2.PW display a significantly reduced median and maximal lifespan compared to controls.

Expression of 5-HT1AKK108407 under the control of Scer\GAL4ey-OK107 in adult male flies results in reduced resistance to starvation and a reduction in lifespan compared to controls.

Flies expressing 5-HT1AKK108407 under the control of Scer\GAL4Ilp2.PW display a decreased tolerance to heat. Likewise, these flies require increased time to recover from cold coma induced by exposure to 0[o]C for 4 hours.

Expression of 5-HT1AKK108407 under the control of Scer\GAL4ey-OK107 in adult male flies results in a significant reduction of lipid levels compared to control flies at 12 and 24 hours of starvation.

Adult flies (4-6 days old) expressing 5-HT1AKK108407 under the control of Scer\GAL4Ilp2.PW do not exhibit a significant difference in weight compared to controls.

Temporal down-regulation of 5-HT1A through expression of 5-HT1AKK108407 in the whole of the mushroom body under the control of Scer\GAL4ey-OK107 (and Scer\GAL80ts.αTub84B) impairs 3 hour memory.

Knockdown of 5-HT1A expression in the α/β neurons in the mushroom body under the control of Scer\GAL4c739 impairs the formation of 3 hour memory. Cold-induced anesthesia further suppresses the 3 hour memory caused by down-regulation of 5-HT1A in α/β neurons. The presence of Scer\GAL80ts.αTub84B, to minimize any developmental contribution, does not affect the impairment of 3 hour memory.

Knockdown of 5-HT1A expression in the α'/β' neurons (Scer\GAL4c305a) or the &ygr; neurons (Scer\GAL413109) in the mushroom body does not affect the formation of 3 hour memory.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
5-HT1AKK108407
d5-HT1AKK108407
Name Synonyms
Secondary FlyBase IDs
    References (6)