FlyBase Allele Report: Dmel\Wwox[KK108459]

General Information

Symbol

Dmel\Wwox^KK108459

Species

D. melanogaster

Name

FlyBase ID

FBal0235587

Feature type

allele

Associated gene

Dmel\Wwox

Associated Insertion(s)

Carried in Construct

P{KK108459}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108459}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108459

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Choo et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by scrib¹

(O'Keefe et al., 2015)

model of cancer

is exacerbated by ND-23^GD11167

(Choo et al., 2015)

is exacerbated by COX5A^GD5167

(Choo et al., 2015)

is exacerbated by COX5B^GD6659

(Choo et al., 2015)

is exacerbated by ND-42^GD6220

(Choo et al., 2015)

is exacerbated by ND-75^KK108222

(Choo et al., 2015)

is exacerbated by UQCR-Q^KK108730

(Choo et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of neoplasia | larval stage phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of abnormal neuroanatomy | larval stage phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of increased occurrence of cell division | larval stage phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of neoplasia | larval stage phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of abnormal neuroanatomy | larval stage phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of increased occurrence of cell division | larval stage phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of neoplasia | larval stage phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of abnormal neuroanatomy | larval stage phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of increased occurrence of cell division | larval stage phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.PU/Wwox^KK108459 is a non-enhancer of abnormal cell cycle phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Wwox^KK108459 is a suppressor | partially of abnormal size phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Wwox^KK108459 is a non-suppressor of abnormal cell cycle phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Scer\GAL4^da.PU/Wwox^KK108459 is a non-suppressor of neoplasia phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye disc phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye phenotype of COX5A^GD5167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye disc phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye phenotype of COX5B^GD6659, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459/Scer\GAL4^ey.PU is an enhancer of eye phenotype of Scer\GAL4^ey.PU, UQCR-Q^KK108730

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye disc phenotype of ND-75^KK108222, Scer\GAL4^ey.PU

(Choo et al., 2015)

Wwox^KK108459, Scer\GAL4^ey.PU is an enhancer of eye phenotype of ND-23^GD11167, Scer\GAL4^ey.PU

(Choo et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Wwox^KK108459 is a suppressor | partially of larval brain phenotype of Scer\GAL4^da.PU, brat^HMS01121

(Hussain et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The larval brain overgrowth exhibited upon expression of brat^HMS01121 under the control of Scer\GAL4^da.PU is partially suppressed when Wwox^KK108459 is co-expressed. The proportion of defective anaphases or level of cell death seen in larval brains expressing brat^HMS01121 under the control of Scer\GAL4^da.PU is not significantly changed upon co-expression of Wwox^KK108459. The tumor growth rate of larval brain explants expressing brat^HMS01121 under the control of Scer\GAL4^da.PU is unchanged upon co-expression of Wwox^KK108459.

(Hussain et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108350

P{KK108459}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

WWOX<up>RNAi 1</up>

(Choo et al., 2015)

Wwox^KK108459

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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