FlyBase Allele Report: Dmel\Cpsf6[KK108487]

General Information

Symbol

Dmel\Cpsf6^KK108487

Species

D. melanogaster

Name

FlyBase ID

FBal0235601

Feature type

allele

Associated gene

Dmel\Cpsf6

Associated Insertion(s)

Carried in Construct

P{KK108487}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108487}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108487

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Tang et al., 2018)

Phenotype Manifest In

autophagosome | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

embryonic/larval fat body | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

spermatid, with Scer\GAL4^VP16.bam

(Gallicchio et al., 2024)

Detailed Description

Statement

Reference

Larval fat body clones expressing Cpsf6^KK108487 under the control of Scer\GAL4^Act.PU show impaired induction of autophagosomes (identified as mCherry-Atg8 puncta) in response to starvation.

(Tang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cpsf6^KK108487, Scer\GAL4^Act.PU is a suppressor | partially of decreased cell size | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Tsc1^UAS.cPa, gig^UAS.cTa

(Tang et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cpsf6^KK108487, Scer\GAL4^Act.PU is a suppressor | partially of embryonic/larval fat body | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Tsc1^UAS.cPa, gig^UAS.cTa

(Tang et al., 2018)

Cpsf6^KK108487, Scer\GAL4^Act.PU is a suppressor | partially of autophagosome | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Tsc1^UAS.cPa, gig^UAS.cTa

(Tang et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107147

P{KK108487}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG7185^KK108487

Cpsf6^KK108487

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close