FlyBase Allele Report: Dmel\foxo[KK108590]

General Information

Symbol

Dmel\foxo^KK108590

Species

D. melanogaster

Name

FlyBase ID

FBal0235673

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{KK108590}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108590}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108590

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

embryonic/larval neuromuscular junction, with Scer\GAL4^elav.PLu

(Nechipurenko and Broihier, 2012)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaD, with Scer\GAL4²²¹

(Iyer et al., 2013)

microtubule, with Scer\GAL4^elav.PLu

(Nechipurenko and Broihier, 2012)

wing, with Scer\GAL4^Bx-MS1096

(Schertel et al., 2015)

Detailed Description

Statement

Reference

Expression of foxo^KK108590 under the control of Scer\GAL4^Bx-MS1096 results in male flies with severe wing size and patterning defects.

Expression of foxo^KK108590 under the control of Scer\GAL4^Bx-MS1096 results in female flies with weak wing size and patterning defects.

(Schertel et al., 2015)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal cell cycle exit of pupal neuroblasts.

(Homem et al., 2014)

Expression of foxo^KK108590 under the control of Scer\GAL4^phm.PO results in larvae that undergo the 'critical weight' ecdysone peak at reduced sizes compared to controls in response to starvation. It occurs at the same age as control flies.

Expression of foxo^KK108590 under the control of Scer\GAL4^phm.PO in starved larvae results in male pharate adults with a slight, but significantly reduced body size compared to controls. Females are similar to controls.

(Koyama et al., 2014)

Expression of foxo^KK108590 under the control of Scer\GAL4^Appl.G1a does not exhibit defects in locomotory ability.

(Wang et al., 2014)

Expression of foxo^KK108590 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of foxo^KK108590 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

(Iyer et al., 2013)

Neuronal knock-down of foxo through expression of foxo^KK108590 under the control of Scer\GAL4^elav.PLu results in enhanced microtubule stability in neuromuscular junctions compared to controls.

(Nechipurenko and Broihier, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^phtm.PO, foxo^KK108590 has decreased body size | pharate adult stage phenotype, enhanceable by usp^JF02546/Scer\GAL4^phtm.PO

(Koyama et al., 2014)

Enhancer of

Statement

Reference

foxo^KK108590/Scer\GAL4^phtm.PO is an enhancer of decreased body size | pharate adult stage | nutrition conditional phenotype of Scer\GAL4^phtm.PO, usp^JF02546

(Koyama et al., 2014)

Suppressor of

Statement

Reference

foxo^KK108590/Scer\GAL4^Cg.PA is a suppressor | partially of abnormal starvation stress response | adult stage phenotype of Scer\GAL4^Cg.PA, Xbp1^KK102632

(Zhao et al., 2021)

foxo^KK108590/Scer\GAL4^Cg.PA is a suppressor | partially of increased mortality | adult stage phenotype of Scer\GAL4^Cg.PA, Xbp1^KK102632

(Zhao et al., 2021)

foxo^KK108590/Scer\GAL4^Cg.PA is a suppressor | partially of decreased size | adult stage phenotype of Scer\GAL4^Cg.PA, Xbp1^KK102632

(Zhao et al., 2021)

Scer\GAL4^Act.PU/foxo^KK108590 is a suppressor of decreased size | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Xbp1^KK102632

(Zhao et al., 2021)

Scer\GAL4^Act.PU/foxo^KK108590 is a suppressor of decreased cell size | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Xbp1^KK102632

(Zhao et al., 2021)

foxo^KK108590, Scer\GAL4^pnr-MD237 is a suppressor of visible phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor | partially of visible phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^pnr-MD237 is a suppressor of increased cell death | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor of increased cell death phenotype of Hsap\APP^695.UAS, Scer\GAL4^ptc-559.1

(Wang et al., 2014)

foxo^KK108590, Scer\GAL4^Appl.G1a is a suppressor of abnormal locomotor behavior phenotype of Hsap\APP^695.UAS, Scer\GAL4^Appl.G1a

(Wang et al., 2014)

Other

Statement

Reference

Scer\GAL4^phtm.PO, foxo^KK108590, usp^JF02546 has abnormal developmental rate | nutrition conditional phenotype

(Koyama et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

foxo^KK108590/Scer\GAL4^Cg.PA is a suppressor | partially of lipid droplet | adult stage phenotype of Scer\GAL4^Cg.PA, Xbp1^KK102632

(Zhao et al., 2021)

Scer\GAL4^Act.PU/foxo^KK108590 is a suppressor of lipid droplet | somatic clone | larval stage phenotype of Scer\GAL4^Act.PU, Xbp1^KK102632

(Zhao et al., 2021)

Scer\GAL4^Act.PU/foxo^KK108590 is a suppressor of larval fat cell | somatic clone phenotype of Scer\GAL4^Act.PU, Xbp1^KK102632

(Zhao et al., 2021)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor | partially of anterior crossvein | adult stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^pnr-MD237 is a suppressor of presumptive scutellum | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^pnr-MD237 is a suppressor of scutellum | adult stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo^KK108590, Scer\GAL4^ptc-559.1 is a suppressor of anterior crossvein phenotype of Hsap\APP^695.UAS, Scer\GAL4^ptc-559.1

(Wang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of usp^JF02546 and foxo^KK108590 under the control of Scer\GAL4^phm.PO enhances the increase in size at which the 'critical weight' ecdysone peak takes place in response to starvation compared to that seen with either transgene alone. The critical weight takes place significantly earlier than in controls.

Co-expression of foxo^KK108590 and usp^JF02546 under the control of Scer\GAL4^phm.PO in starved larvae dramatically enhances the reduction in pharate adult body size seen with either transgene alone.

(Koyama et al., 2014)

Xenogenetic Interactions

Statement

Reference

Co-expression of foxo^KK108590 significantly partially suppresses the increased cell death in third instar larval wing discs and the loss of the anterior crossvein in adult wings induced by expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^ptc-559.1. Co-expression of foxo^KK108590 significantly suppresses the increased cell death in the notum tips of third instar larval wing discs and the small scutellum phenotype in adults induced by expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237.

(Wang et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107786

P{KK108590}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

foxo^KK108590

foxo^Ri

(Gupta and Stocker, 2020)

Name Synonyms

Secondary FlyBase IDs

References (15)

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