FlyBase Allele Report: Dmel\Tak1[KK108611]

General Information

Symbol

Dmel\Tak1^KK108611

Species

D. melanogaster

Name

FlyBase ID

FBal0235687

Feature type

allele

Associated gene

Dmel\Tak1

Associated Insertion(s)

Carried in Construct

P{KK108611}

Also Known As

Tak1 RNAi, UAS-dTAK1-IR, UAS-Tak1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108611}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108611

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^r4

(Liu et al., 2016)

lethal - all die during larval stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

lethal - all die during P-stage, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

some die during larval stage, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Tak1^KK108611 under the control of Scer\GAL4^C587 (together with Dicer-2, for a more efficient RNAi) does not induce any major L3 spermatogenesis defects.

(La Marca et al., 2019)

Expression of Tak1^KK108611 driven in the fat body of male flies by Scer\GAL4^r4 significantly decreases survival of flies in response to Gram-negative bacteria (Erwinia carotovora carotovora 15 or Escherichia coli), compared to controls. Bacterial load (measured as colony forming units 24hr post infection) of Erwinia carotovora carotovora 15 significantly increases in adult flies, compared to controls.

(Liu et al., 2016)

Expression of Tak1^KK108611 RNAi under the control Scer\GAL4^Hml.Δ driver does not rescue the lowered survival of adult flies on lard-supplemented diet compared to controls.

(Woodcock et al., 2015)

RNAi knockdown of Tak1, through expression of Tak1^KK108611 in the posterior compartment of the wing disc, under the control of either Scer\GAL4^en.PU or Scer\GAL4^hh.PU, does not affect levels of cell death.

(Wong et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^hh.PU, Tak1^KK108611, mad2^GD16427 has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^hh.PU

(Wong et al., 2014)

Scer\GAL4^en.PU, Tak1^KK108611, mad2^GD16427 has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Wong et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^C587/Tak1^KK108611 is a suppressor | partially of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Tak1^KK108611/Scer\GAL4^Act5C.PP is a suppressor of cell lethal | somatic clone phenotype of Scer\GAL4^Act5C.PP, egr^UAS.cMa

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5/Tak1^KK108611 is a suppressor | partially of increased cell death phenotype of Scer\GAL4^rn-GAL4-5, egr^UAS.cMa

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5/Tak1^KK108611 is a suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Andersen et al., 2015)

Tak1^KK108611, Scer\GAL4^dpp.blk1 is a suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

Tak1^KK108611, Scer\GAL4^cv-c-C5 is a non-suppressor of abnormal size | adult stage phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Tak1^KK108611, Scer\GAL4^cv-c-C5 is a non-suppressor of visible | adult stage phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Other

Statement

Reference

Scer\GAL4^hh.PU, Tak1^KK108611, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Scer\GAL4^en.PU, Tak1^KK108611, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^hh.PU, Tak1^KK108611, mad2^GD16427 has wing disc phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^hh.PU

(Wong et al., 2014)

Scer\GAL4^en.PU, Tak1^KK108611, mad2^GD16427 has wing disc phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Wong et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^C587/Tak1^KK108611 is a suppressor | partially of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Tak1^KK108611/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cMa

(Andersen et al., 2015)

Tak1^KK108611, Scer\GAL4^dpp.blk1 is a suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

Tak1^KK108611, Scer\GAL4^cv-c-C5 is a non-suppressor of wing phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Other

Statement

Reference

Scer\GAL4^hh.PU, Tak1^KK108611, mad2^GD16427 has wing disc phenotype

(Wong et al., 2014)

Scer\GAL4^en.PU, Tak1^KK108611, mad2^GD16427 has wing disc phenotype

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The small wing size induced by Scer\GAL4^C5-controlled expression of Dad1^GD1006 is not suppressed by the co-expression of Tak1^KK108611.

(Zhang et al., 2016)

There is a significant reduction in chromosome instability tolerance induced by mad2^GD16427 expression, when Tak1^KK108611 is expressed in imaginal wing discs under the control of Scer\GAL4^en.PU or Scer\GAL4^hh.PU. This is concomitant with an increase in the level of cell death. Consistent with high levels of cell death and consequent loss of tissue, adult wings show notching when JNK signalling is reduced in a chromosome instability background (through expression of mad2^GD16427).

(Wong et al., 2014)

Xenogenetic Interactions

Statement

Reference

(Wong et al., 2014)

Co-expression of Tak1^KK108611 suppresses the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101357

P{KK108611}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tak1^KK108611

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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