FlyBase Allele Report: Dmel\Mmp1[KK108894]

General Information

Symbol

Dmel\Mmp1^KK108894

Species

D. melanogaster

Name

FlyBase ID

FBal0235905

Feature type

allele

Associated gene

Dmel\Mmp1

Associated Insertion(s)

Carried in Construct

P{KK108894}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108894}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108894

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.cUa.UAS, dlg1^RNAi.UAS.cUa

(Lodge et al., 2021)

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Portela et al., 2019)

ameliorates hematologic cancer

modeled by mxc¹

(Takarada et al., 2023, Kurihara et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

increased efficacy of long-term memory | adult stage, with Scer\GAL4^DBD.Mef2.247

(Widmer et al., 2018)

Phenotype Manifest In

fat body, with Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Detailed Description

Statement

Reference

Third instar larvae expressing Mmp1^KK108894 under the control of Scer\GAL4^repo do not show major changes in brain size or brain glial network, and do not show changes in the number of synapses at the neuromuscular junction.

(Portela et al., 2019)

Knockdown of Mmp1^KK108894 driven by Scer\GAL4^Act.PU during adulthood (using Scer\GAL80^ts.αTub84B) does not cause a reduction in egg laying compared to wild type.

(Deady et al., 2015)

Down-regulation of Mmp1 in fat bodies, through the expression of Mmp1^KK108894 under the control of Scer\GAL4^Lsp2.PH, results in a significant delay in fat body cell dissociation during metamorphosis.

(Jia et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mmp1^KK108894, Scer\GAL4^Lsp2.PH has abnormal developmental rate phenotype, enhanceable by Mmp1^KK108894, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Enhancer of

Statement

Reference

Mmp1^KK108894, Scer\GAL4^Lsp2.PH is an enhancer of abnormal developmental rate phenotype of Mmp2^KK104713, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Mmp1^KK108894, Scer\GAL4^Lsp2.PH is an enhancer of abnormal developmental rate phenotype of Mmp1^KK108894, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^He.PZ/Mmp1^KK108894 is a suppressor of abnormal cell adhesion | larval stage phenotype of mxc¹

(Takarada et al., 2023)

Scer\GAL4^He.PZ/Mmp1^KK108894 is a suppressor of abnormal cell migration | larval stage phenotype of mxc¹

(Takarada et al., 2023)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of short lived phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mmp1^KK108894, Scer\GAL4^Lsp2.PH has fat body phenotype, enhanceable by Mmp1^KK108894, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Enhancer of

Statement

Reference

Mmp1^KK108894, Scer\GAL4^Lsp2.PH is an enhancer of fat body phenotype of Mmp2^KK104713, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Mmp1^KK108894, Scer\GAL4^Lsp2.PH is an enhancer of fat body phenotype of Mmp1^KK108894, Scer\GAL4^Lsp2.PH

(Jia et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^He.PZ/Mmp1^KK108894 is a suppressor of larval circulating hemocyte | ectopic | increased number phenotype of mxc¹

(Takarada et al., 2023)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of synapse | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Mmp1^KK108894, Scer\GAL4^repo is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Mmp1^KK108894 in loser cell clones that are confronted with Myc^αTub84B.PBb-expressing super-competitors does not alter the number/size of loser cell clones, nor does it significantly affect hemocyte number per wing disc.

(Casas-Tintó et al., 2015)

Simultaneous down-regulation of Mmp1 and Mmp2 in the fat body during metamorphosis, through expression of Mmp2^KK104713 and Mmp1^KK108894 under the control of Scer\GAL4^Lsp2.PH results in a more significant delay than reducing the expression of either Mmp1 or Mmp2 alone.

(Jia et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101505

P{KK108894}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmp1^KK108894

Mmp1^Ri

(Lodge et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (16)

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