Allele Dmel\Tsp26A^KK109274

General Information
Symbol	Dmel\Tsp26A^KK109274	Species	D. melanogaster
Name		FlyBase ID	FBal0236190
Feature type	allele	Associated gene	Dmel\Tsp26A

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Keleman et al., 2009.8.5) in vitro construct - RNAi (Keleman et al., 2009.8.5)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..310
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Keleman et al., 2009.8.5)
Carried in construct	P{KK109274} (Keleman et al., 2009.8.5, Dornier et al., 2012)
Associated Sequence Features	dsRNA-KK109274
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	sensory mother cell \| pupal stage \| somatic clone \| supernumerary, with Scer\GAL4^tub.PU (Dornier et al., 2012)
Detailed Description
	Statement Reference Clones cells expressing Tsp26A[KK109274] in the notum of the developing pupae under the control of Scer\GAL4[tub.PU] are more likely to become sensory organ precursor cells compared to control cells. (Dornier et al., 2012)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference +/Df(3R)Tsp86DΔ3, Scer\GAL4^ap-md544, Tsp26A^KK109274, Tsp3A^NIG.10742R has visible \| adult stage phenotype (Dornier et al., 2012)
Phenotype Manifest In
Other
Statement Reference +/Df(3R)Tsp86DΔ3, Scer\GAL4^ap-md544, Tsp26A^KK109274, Tsp3A^NIG.10742R has mechanosensory chaeta phenotype (Dornier et al., 2012) +/Df(3R)Tsp86DΔ3, Scer\GAL4^ap-md544, Tsp26A^KK109274, Tsp3A^NIG.10742R has sensory mother cell \| supernumerary phenotype (Dornier et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Flies co-expressing Tsp3A[NIG.10742R] and Tsp26A[KK109274] under the control of Scer\GAL4[ap-md544] in a Df(3R)Tsp86DΔ3/+ background exhibit a bristle loss phenotype associated with the specification of too many SOPs and the transformation of external cells into internal cells, including neurons. Co-expression of Tsp3A[NIG.10742R], Tsp86D[NIG.4591R] and Tsp26A[KK109274] in border cells under the control of Scer\GAL4[slbo.2.6] and Scer\GAL4[c306] results in fewer border cells and delayed migration. (Dornier et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
VDRC	v101473 P{KK109274}VIE-260B
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Tsp26A^KK109274
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Dornier et al., 2012, J. Cell Biol. 199(3): 481--496 TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. [FBrf0219816]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]

Allele Dmel\Tsp26AKK109274

Allele Dmel\Tsp26A^KK109274